Dynamic interplay of oncogenes and T cells induces PD-L1 in the tumor microenvironment.
Dynamic interplay of oncogenes and T cells induces PD-L1 in the tumor microenvironment.
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DOI：
10.1158/2159-8290.cd-13-0775
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发表时间：
2013-12
期刊：
影响因子：
28.2
通讯作者：
Vonderheide RH
中科院分区：
文献类型：
--
作者：
Rech AJ;Vonderheide RH
最近发现肿瘤浸润性T细胞以旁分泌方式上调免疫抑制途径，如PD-1配体(PD-L1)，但肿瘤细胞对PD-L1的内在调节是另一种可能的机制。在本期《癌症发现》杂志上，Akbay及其同事展示了通过突变的EGFR在小鼠肺肿瘤细胞中直接上调肿瘤PD-L1的信号，以及对该途径的治疗性阻断提高了EGFR驱动的临床前模型的存活率-突出了癌细胞生物学和免疫生物学的动态相互作用和治疗机会。
Tumor infiltrating T cells have recently been found to upregulate immunosuppressive pathways, such as PD-1 ligand (PD-L1), in a paracrine fashion on tumor cells, but tumor cell intrinsic regulation of PD-L1 is another potential mechanism. In this issue of Cancer Discovery, Akbay and colleagues show that signaling via mutant EGFR in murine lung tumor cells directly upregulates tumor PD-L1 and that therapeutic blockade of this pathway improves survival in EGFR-driven preclinical models – highlighting the dynamic interplay and therapeutic opportunities of cancer cell biology and immune biology.