Articular cartilage repair: the role of bone morphogenetic proteins
Articular cartilage repair: the role of bone morphogenetic proteins
复制标题
关节软骨修复：骨形态发生蛋白的作用
DOI：
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发表时间：
2002
影响因子：
2.7
通讯作者：
Slobodan Vukicevic
中科院分区：
文献类型：
--
作者：
Marko Pećina;M. Jelić;S. Martinović;M. Haspl;Slobodan Vukicevic
关节表面修复仍然是现代医学的一个主要挑战，因为启动软骨形成、成熟和修复的因素知之甚少。特定的生物学挑战包括产生的软骨的质量和数量的变化，随着年龄的增长反应性降低，与邻近软骨的结合，以及软骨下骨团的恢复。软骨损伤会引发特定的修复反应。在无胶原损伤的关节软骨病变中，发生非胶原基质的损失，最终导致受损基质[6]的完全修复。在更严重的情况下，当纤维网受损和细胞死亡时，关节软骨不会愈合[33,44]。在过去几十年的临床骨科中，治疗软骨缺损的技术包括磨蚀、钻孔、底层骨微骨折、自体组织移植、同种异体移植和细胞移植[1,3,15,16,21,26,27,28,34,40,41,51]。近年来，人们已经了解到各种刺激软骨细胞分化和软骨基质生成的生长因子，但迄今为止，还没有一种方法能够完全成功地获得结构合理的再生关节软骨。
Joint surface repair is still a major challenge in modernmedicine because the factors initiating cartilage forma-tion, maturation, and repair are poorly understood. Spe-cific biological challenges include the variable qualityand quantity of the cartilage produced, decreasing re-sponsiveness with age, bonding to the adjacent cartilage,and restoration of the subchondral bone [36]. Injury tocartilage initiates a specific reparative response. In le-sions of the articular cartilage with no collagen damage aloss of non-collagenous matrix occurs, leading eventual-ly to complete repair of the damaged matrix [6]. In moresevere cases, where there is a damage of the fibrillar net-work and cell death, the articular cartilage does not heal[33, 44].Over the past several decades in clinical orthopaedicwork, techniques to treat chondral defects included abra-sion, drilling, micro-fracturing of the underlying bone,tissue autografts, allografts, and cell transplantation [1,3, 15, 16, 21, 26, 27, 28, 34, 40, 41, 51]. In recent yearsmore has been learned about various growth factors thatstimulate chondrocyte differentiation and cartilage ma-trix production, but to date no procedure has been fullysuccessful in achieving properly structured regenerativearticular cartilage.
DOI：
10.2106/00004623-199304000-00009
发表时间：
1993-04-01
影响因子：
5.3
作者：
SHAPIRO, F;KOIDE, S;GLIMCHER, MJ
通讯作者：
GLIMCHER, MJ