A symmetrical optical waveguide based surface plasmon resonance biosensing system
A symmetrical optical waveguide based surface plasmon resonance biosensing system
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基于对称光波导的表面等离子体共振生物传感系统
DOI：
10.1016/j.snb.2013.05.005
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发表时间：
2013-08-01
影响因子：
8.4
通讯作者：
He, Yonghong
中科院分区：
文献类型：
--
作者：
Shi, Heng;Liu, Zhiyi;He, Yonghong
在这项工作中，我们提出了一种基于MgF2/Au/MgF2/Analyte的角度询问表面等离子体共振传感器。这种对称结构导致更高的表面电场强度，更长的表面传播长度和深度。通过简单的SPR成像系统，获得了8.1 × 10(-8) RIU的流体方案和3.5 × 10(-7) RIU的大气方案的折射率分辨率。为了证明该系统在生物医学上的应用，我们利用传感器表面的多巴胺膜固定抗体来检测不同浓度的大肠杆菌。该系统对大肠杆菌的检出限为10(3)cfu/mL。(C) 2013 Elsevier B.V.版权所有
In this work, we propose a MgF2/Au/MgF2/Analyte based, angle-interrogation surface plasmon resonance sensor. This symmetrical structure results in higher surface electric field strengths, and longer surface propagation lengths and depths. A refractive index resolution of 8.1 x 10(-8) RIU in fluid protocol and 3.5 x 10(-7) RIU in atmosphere protocol is acquired by a simple SPR imaging system. In order to demonstrate the biomedical applications of this system, we detect Escherichia coli with different concentrations using dopamine film on the sensor surface to immobilize antibodies. A detection limit of 10(3) cfu/mL of E. coli bacteria is acquired from this system. (C) 2013 Elsevier B.V. All rights reserved.