BaZrO3 based non enzymatic single component single step ceramic electrochemical sensor for the picomolar detection of dopamine
BaZrO3 based non enzymatic single component single step ceramic electrochemical sensor for the picomolar detection of dopamine
复制标题
基于 BaZrO3 的非酶单组分单步陶瓷电化学传感器，用于皮摩尔检测多巴胺
DOI：
10.1016/j.ceramint.2021.11.278
复制
发表时间：
2021
影响因子：
5.2
通讯作者：
Nygil Thomas
中科院分区：
文献类型：
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作者：
Jasmine Thomas;P. Anitha;Tony Thomas;Nygil Thomas
采用无煅烧室温共沉淀法一步合成了BaZrO3钙钛矿微晶。利用结构、热分析和显微镜研究了微晶尺寸、金属氧键的存在、热稳定性、缺陷结构、表面形貌。该材料被用于碳糊电极（CPE）的修饰，用于制造先进的传感器。与未改性的电极相比，改性的电极表现出更低的电阻和更好的电荷转移。使用CV和DPV研究的电化学特性显示出对多巴胺（DA）检测的高电流灵敏度。该修饰电极对尿酸（UA）和抗坏血酸（AA）的检测限分别为500 pM和500 nM，对DA的检测限为5 pM。所开发的传感器可以定量的DA在尿酸（UA）和抗坏血酸（AA）的存在下。混合样品分析、干扰研究、稳定性分析等证明了所研制传感器的性能。血浆和尿液中的真实的样品分析标志着所开发的传感器的实用性。
BaZrO3perovskite crystallites were synthesized in a single step using a calcination free room temperature co precipitation method. Crystallite size, presence of metal oxygen bond, thermal stability, defect structure, surface morphology were studied using structural, thermal and microscopic investigations. This material was used for the modification of carbon paste electrode (CPE) for the fabrication of an advanced sensor. The modified electrode exhibited lower resistance and better charge transfer compared to an unmodified electrode. The electrochemical characteristics investigated using CV and DPV showed high current sensitivity towards the detection of dopamine (DA). The modified electrode achieved a remarkable low concentration of 5 pM detection limit level for the detection of DA. Limit of detection for co existing molecules of uric acid (UA) and ascorbic acid (AA) were 500 pM and 500 nM respectively. The developed sensor could quantify the DA in the presence of uric acid (UA) and ascorbic acid (AA). Mixed sample analysis, interference studies, stability analysis etc prove the competence of the developed sensor. Real sample analysis in blood plasma and urine marked the practical utility of the developed sensor.