Vasopressin release in response to nausea-producing agents and cholecystokinin in monkeys.
Vasopressin release in response to nausea-producing agents and cholecystokinin in monkeys.
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猴子对恶心产生剂和胆囊收缩素作出反应而释放加压素。
DOI：
10.1152/ajpregu.1987.252.4.r749
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Stricker,EM
中科院分区：
文献类型：
--
作者：
Verbalis,JG;Richardson,DW;Stricker,EM
给成年猴注射氯化锂和硫酸铜可引起血浆加压素（AVP）水平显著升高，而血浆催产素（OT）水平无显著升高。给予这些药物的7只动物中有5只产生呕吐，支持恶心作为AVP释放的主要刺激。胆囊收缩素（CCK）给药后，AVP释放无OT释放。虽然大多数猴子对10微克/千克的CCK有呕吐反应，但1微克/千克的剂量也使血浆AVP水平显著升高，这在任何动物中都没有引起呕吐。这些发现与先前在大鼠中的结果形成鲜明对比，该结果表明氯化锂、硫酸铜和CCK各自刺激OT而不是AVP释放。尽管这种种间差异，显着的神经垂体激素分泌反应恶心产生剂和CCK表明，AVP分泌在猴子中，类似于OT分泌在大鼠中，可能反映中枢通路介导恶心和/或抑制食物摄入的激活，即使没有明显的疾病。
Administration of lithium chloride and copper sulfate to adult monkeys caused marked elevations in plasma vasopressin (AVP) levels without significant increases in plasma oxytocin (OT) levels. Emesis was produced in five of the seven animals given these agents, in support of nausea as the main stimulus to AVP release. A similar pattern of AVP release without OT release was found after administration of cholecystokinin (CCK). Although most monkeys vomited in response to 10 micrograms/kg of CCK, a significant increase in plasma AVP levels also was produced with a dose of 1 microgram/kg, which did not produce emesis in any animal. These findings are in marked contrast with previous results in rats, which indicated that lithium chloride, copper sulfate, and CCK each stimulated OT rather than AVP release. Despite this interspecies difference, the significant neurohypophysial hormone secretion in response to both nausea-producing agents and CCK suggests that AVP secretion in monkeys, similar to OT secretion in rats, might reflect activation of central pathways mediating nausea and/or inhibition of food intake, even when overt illness is not produced.