Effects of Lutein/Zeaxanthin Supplementation on the Cognitive Function of Community Dwelling Older Adults: A Randomized, Double-Masked, Placebo-Controlled Trial
Effects of Lutein/Zeaxanthin Supplementation on the Cognitive Function of Community Dwelling Older Adults: A Randomized, Double-Masked, Placebo-Controlled Trial
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DOI：
10.3389/fnagi.2017.00254
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发表时间：
2017-08-03
影响因子：
4.8
通讯作者：
Renzi-Hammond, Lisa M.
中科院分区：
文献类型：
--
作者：
Hammond, Billy R., Jr.;Miller, L. Stephen;Renzi-Hammond, Lisa M.
背景资料：中枢神经系统中高水平的叶黄素类胡萝卜素叶黄素（L）和玉米黄质（Z）与社区居住的老年人认知功能的改善有关。在这项研究中，我们测试了补充L和Z对老年男性和女性的基线cognitive abilities.Objective的影响：这项研究的目的是确定是否补充L+Z可以改善社区居住的老年人的认知功能。设计：双盲，随机，安慰剂对照试验。共有62名老年人被随机分组，接受12 mg L+Z或视觉上相同的安慰剂。来自51名参与者（M = 73.7岁）的数据可用于分析。使用异色闪烁光度法作为皮质L+ Z水平的生物标志物，以精神病方式测量视网膜L+ Z水平（黄斑色素光密度，MPOD）。结果：与服用安慰剂的参与者相比，接受活性L+Z补充剂的参与者在MPOD（p < 0.03）、复杂注意力（p < 0.02）和认知灵活性领域（p < 0.04）方面有统计学显著性增加。在执行功能领域也观察到趋势（p = 0.073）。仅在男性参与者中，补充剂改善了复合记忆（p = 0.04）。结论：补充L+Z改善了社区居住的老年男性和女性的认知功能。
Background: High levels of xanthophyll carotenoids lutein (L) and zeaxanthin (Z) in the central nervous system have been previously correlated with improved cognitive function in community-dwelling older adults. In this study, we tested the effects of supplementing L and Z on older men and women with a range of baseline cognitive abilities.Objective: The purpose of this study was to determine whether or not supplementation with L+Z could improve cognitive function in community-dwelling, older adults.Design: Double-masked, randomized, placebo-controlled trial. A total of 62 older adults were randomized into groups receiving either 12 mg L+Z or a visually identical placebo. Data from 51 participants (M = 73.7 years) were available for analysis. Retinal L+Z levels (macular pigment optical density, MPOD) were measured psychophysically using heterochromatic flicker photometry as a biomarker of cortical L+Z levels. Cognitive function was measured using the CNS Vital Signs computerized test platform.Results: Participants receiving the active L+Z supplement had statistically significant increases in MPOD (p < 0.03) and improvements in complex attention (p < 0.02) and cognitive flexibility domains (p < 0.04), relative to participants taking the placebo. A trend was also seen for the executive function domain (p = 0.073). In male participants only, supplementation yielded improved composite memory (p = 0.04).Conclusions: Supplementation with L+Z improved cognitive function in community-dwelling, older men and women.