Near-infrared-responsive nanoplatforms integrating dye-sensitized upconversion and heavy-atom effect for enhanced photodynamic therapy efficacy
Near-infrared-responsive nanoplatforms integrating dye-sensitized upconversion and heavy-atom effect for enhanced photodynamic therapy efficacy
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DOI：
10.1016/j.nantod.2023.102089
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发表时间：
2024-02
期刊：
影响因子：
17.4
通讯作者：
Chong Tan;Xingjun Li;Zhuo Li;Shan Lu;Fei Wang;Yan Liu;Fei Wen;Renfu Li;Datao Tu;
中科院分区：
文献类型：
--
作者：
Chong Tan;Xingjun Li;Zhuo Li;Shan Lu;Fei Wang;Yan Liu;Fei Wen;Renfu Li;Datao Tu;
近年来，用于光动力学治疗（PDT）的近红外（NIR）响应性上转换纳米平台的发展引起了相当大的关注，但仍然受到PDT疗效低的限制。在此，我们设计并合成了一个近红外响应纳米平台，通过集成镧系元素掺杂的上转换纳米粒子（UCNPs），铂修饰的卟啉金属有机框架（PMOFs）和近红外染料IR 808到一个核-壳结构的高效抗菌PDT。PMOF壳层不仅可以作为光敏剂吸收UCNPs的上转换发光（UCL）以产生单线态氧（1 O2），还可以作为负载IR 808的多孔主体材料。值得注意的是，我们发现Pt（II）的重原子效应可以同时提高IR 808和卟啉配体Pt-TCPP的系间穿越（S1→T1）效率，从而提高染料三重态敏化UCNPs的UCL和光敏剂的1 O2产生能力。结果表明，该纳米平台具有良好的1 O2产生能力，对耐甲氧西林金黄色葡萄球菌（MRSA）具有显著的杀菌活性，杀灭率为5.27 log 10（> 99.999%）。这些发现将为设计高效的PDT纳米平台铺平道路，并加速其生物医学应用。
The development of near-infrared (NIR)-responsive upconversion nanoplatforms for photodynamic therapy (PDT) has attracted considerable attention in recent years, but is still limited by the low PDT efficacy. Herein, we designed and synthesized a NIR-responsive nanoplatform through the integration of lanthanide-doped upconversion nanoparticles (UCNPs), Pt-decorated porphyrin metal-organic frameworks (PMOFs) and NIR dye IR808 into a core-shell structure for highly efficient antibacterial PDT. The PMOF shell can function not only as a photosensitizer to absorb the upconversion luminescence (UCL) of UCNPs for singlet oxygen (1O2) generation, but also as a porous host material for loading of IR808. Remarkably, we demonstrated that the heavy-atom effect of Pt(II) can simultaneously enhance the intersystem crossing (S1→T1) efficiencies of the IR808 and the porphyrin ligand Pt-TCPP, resulting in the enhancement of dye-triplet-sensitized UCL of UCNPs and1O2production capacity of the photosensitizer. As a result, the proposed nanoplatform exhibited excellent1O2production and a significant bactericidal activity against methicillin-resistantStaphylococcus aureus(MRSA) with 5.27 log10(> 99.999%) killing efficacy. These findings will pave the way for designing highly efficient PDT nanoplatforms and accelerate their biomedical applications.