Stimuli-Responsive Capsule Membranes for Controlled Release in Pharmaceutical Applications.
Stimuli-Responsive Capsule Membranes for Controlled Release in Pharmaceutical Applications.
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DOI：
10.2174/1381612822666161021141429
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发表时间：
2016-12
影响因子：
3.1
通讯作者：
Zhuang Liu;Xiao‐Jie Ju;Wei Wang;Rui Xie;Lu Jiang;Qianming Chen;Yan-Qiong Zhang;Jiang-Feng Wu;L. Chu
中科院分区：
文献类型：
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作者：
Zhuang Liu;Xiao‐Jie Ju;Wei Wang;Rui Xie;Lu Jiang;Qianming Chen;Yan-Qiong Zhang;Jiang-Feng Wu;L. Chu
背景在常规药物递送中，一旦服用药物，血液中的药物浓度升高，然后达到峰值和下降。由于每种药物都有一个水平，高于这个水平是有毒的，低于这个水平是无效的，所以在特定时间病人体内的药物浓度取决于对处方常规的依从性。方法为了提高药物的疗效和减少药物的副作用，需要药物载体具有良好的给药量和可控的释药性能。具有智能门控膜或基于水凝胶的膜作为胶囊壳的刺激响应胶囊是理想的候选者。智能胶囊膜能够在大的内部体积内有效地封装药物，并且响应性门控膜或基于水凝胶的膜可以响应于环境刺激来控制封装的药物的释放速率。触发刺激可以是与特定疾病相对应的人工刺激或天然刺激，如温度、pH、葡萄糖浓度、特定离子、光和磁场。结果本文综述了近年来用于药物控释的刺激响应型胶囊膜的研究进展，包括两种不同结构的刺激响应型胶囊膜，分别用于开/关释放和突释，实现了病例依赖性开/关释放和突释的潜在应用。结论智能胶囊膜的优点是胶囊内部空间可控，可容纳所需剂量的药物载体，并以刺激响应膜为囊壳，实现药物在所需部位和/或时刻的释放。然而，刺激响应型胶囊膜系统要在生物医学领域得到广泛应用还面临着一些实际困难。未来的工作应集中在改善生物相容性，生物降解性和刺激响应性的胶囊膜，简单和可扩展的制造技术，进一步减少胶囊的大小，更有效的在体内应用，和多样化的多隔室胶囊结构与多刺激响应特性的控制释放。
BACKGROUND In conventional drug delivery, the drug concentration in the blood raises once the drug taken, and then peaks and declines. Since each drug has a level above which it is toxic and another level below which it is ineffective, the drug concentration in a patient at a particular time depends on compliance with the prescribed routine. METHODS To achieve more effective efficacy and fewer side effects of drugs, the drug carriers with desirable dosing and controllable release property of drugs are highly desired. Stimuli-responsive capsules with smart gating membranes or hydrogel-based membranes as capsule shells are ideal candidates. The smart capsule membranes enable efficient encapsulation of drugs within the large inner volume, and the responsive gating membranes or hydrogel-based membranes could control the release rate of encapsulated drugs in responding to environmental stimuli. The trigger stimuli could be either artificial or natural ones corresponding to specific diseases, such as temperature, pH, glucose concentration, specific ion, light, and magnetic field. RESULTS This review highlights the recent development in stimuli-responsive capsule membranes for controlled release in pharmaceutical applications, including two types of stimuli-responsive capsule membranes with different architectures for on/off release and burst release, which can achieve potential uses of case-dependent on/off release and burst release. CONCLUSION The preponderances of the smart capsule membranes are that the capsules are with controllable inner space for drug vehicles with desired dose and stimuli-responsive membrane as shell to release drugs at a desired site and/or moment. However, the actual difficulties for the stimuli-responsive capsule membrane systems to go before they can be applied widely in the biomedical fields are discussed. The future works should focus on the improvements of biocompatibility, biodegradability and stimuli-responsiveness of the capsule membranes, easy and scalable fabrication techniques with further decrease of the capsule size for more efficient in vivo applications, and the diversification of the multi-compartmental capsule architectures with multi-stimuli-responsive characteristics for controlled release.