Photoresponsive nanogels formed by the self-assembly of spiropyrane-bearing pullulan that act as artificial molecular chaperones
Photoresponsive nanogels formed by the self-assembly of spiropyrane-bearing pullulan that act as artificial molecular chaperones
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DOI：
10.1021/bm049860o
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发表时间：
2004-09-01
影响因子：
6.2
通讯作者：
Akiyoshi, K
中科院分区：
文献类型：
--
作者：
Hirakura, T;Nomura, Y;Akiyoshi, K
通过螺吡喃普鲁兰多糖（Spiropyrane-bearing pullulan，SpP）的自组装制备了新型光响应性纳米凝胶。通过疏水性螺吡喃和亲水性汞之间的异构化，可以通过光刺激来控制纳米凝胶的溶液性质。研究了纳米凝胶在蛋白质复性中的分子伴侣样活性。柠檬酸合酶的活性显着增加时，两亲性的SpP纳米凝胶的光刺激开关。
Novel photoresponsive nanogels were prepared by the self-assembly of spiropyrane-bearing pullulan (SpP). The solution properties of the nanogels could be controlled by photostimulation via isomerization between hydrophobic spiropyrane and hydrophilic merocyanine. The molecular chaperone-like activity of the nanogels in protein refolding was investigated. The activity of citrate synthase significantly increased when the amphiphilicity of SpP nanogels was switched by photostimulation.