Results of magnetic resonance imaging in long-term manganese dioxide-exposed workers
Results of magnetic resonance imaging in long-term manganese dioxide-exposed workers
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DOI：
10.1006/enrs.2000.4068
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发表时间：
2001-01-01
影响因子：
8.3
通讯作者：
Triebig, G
中科院分区：
文献类型：
--
作者：
Dietz, MC;Ihrig, A;Triebig, G
在一项横断面研究中，研究了职业性锰暴露的神经毒性效应。从90名（男58名，女32名）工人中，11名长期接触高浓度二氧化锰（MnO_2）的男性被定义为接触工人。11名年龄匹配的工人类似的社会经济地位被用作参考组。进行环境空气和生物监测（血液、尿液、毛发）、临床（韦伯斯特评定量表，WRS）、神经生理学（视觉诱发电位（VEP）、神经传导速度（NCV）、脑电图（EEG））和运动性能（Wiener Testsystem）检查。采用苍白球指数（PI），即T-1加权磁共振成像（MRI）平面上苍白球与皮质下额叶白质信号强度的比值乘以100。就个体负荷而言，血锰是最可靠的生物标志物。计算每个工人的累积锰暴露指数（CEI）的“工作暴露矩阵”。WRS、VEP、NCV、EEG和运动功能测试结果均无显著性差异。然而，苍白球指数增加锰接触者。此外，CEI和苍白球指数之间存在统计学显著正相关。其他研究的结果进行了讨论。MRI结果对健康状况的意义以及性别特异性差异应在进一步的随访研究中进行检查。(C)北京大学出版社.
Within a cross-sectional study, the neurotoxic effects of occupational exposure to manganese were examined. From a group of 90 (58 male and 32 female) workers, 11 men with long-term and high exposure to manganese dioxide (MnO2) dust were defined as exposed workers. Eleven age-matched workers of similar socioeconomic status were used as a reference group. Ambient air and biological monitoring (blood, urine, hair), clinical (Webster Rating Scale, WRS), neurophysiological (visual evoked potentials (VEP), nerve conduction velocity (NCV), electroencephalography (EEG)), and motor performance (Wiener Testsystem) examinations were performed. The pallidal index (PI), the ratio of globus pallidus to subcortical frontal white-matter signal intensity in T-1-weighted magnetic resonance imaging (MRI) planes multiplied by 100, was used. For the individual body burden, manganese in blood was the most reliable bio marker. A "job exposure matrix" for the cumulative Mn-exposure index (CEI) was calculated for each worker. The results of WRS, VEP, NCV, EEG, and motor performance tests showed no significant group differences. However, the pallidal index was increased in Mn-exposed persons. Furthermore, a statistically significant positive correlation was found between CEI and pallidal index. The results of other studies are discussed. The meaning of MRI findings for health status as well as gender-specific differences should be examined in further follow-up studies. (C) 2000 Academic Press.