INFLUENCE OF VISCOSITY AND SOLUBILIZATION ON DISSOLUTION RATE
INFLUENCE OF VISCOSITY AND SOLUBILIZATION ON DISSOLUTION RATE
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DOI：
10.1002/jps.2600610206
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发表时间：
1972-01-01
影响因子：
3.8
通讯作者：
PARROTT, EL
中科院分区：
文献类型：
--
作者：
BRAUN, RJ;PARROTT, EL
苯甲酸在蔗糖和甲基纤维素水溶液中的溶出速率与溶出介质的粘度成反比。苯甲酸在聚山梨酯80水溶液中的总溶解度随着表面活性剂浓度的增加而线性增加。随着聚山梨酯80浓度的增加，胶束溶液的粘度增加有限，苯甲酸的溶出速率增加至最大速率，并与总溶解度相关，如Noyes-Whitney关系所示。当聚山梨酯80的浓度超过对应于最大溶出速率的浓度时，溶出速率随着表面活性剂浓度的增加而降低。因为溶解速率与粘度成反比，所以高浓度的聚山梨酯80将胶束溶液的粘度增加到溶解速率减慢的程度，尽管总溶解度大大增加。在保持恒定粘度的胶束溶液中，苯甲酸的总溶解度随着表面活性剂浓度的增加而线性增加。苯甲酸在粘度恒定的胶束溶液中的溶解速率随表面活性剂浓度的增加而逐渐增加，但没有最大速率。
The dissolution rate of benzoic acid in aqueous sucrose and methylcellulose solutions is inversely proportional to the viscosity of the dissolution medium. The total solubility of benzoic acid in aqueous solutions of polysorbate 80 increases linearly as the concentration of the surfactant is increased. As the concentration of polysorbate 80 is increased with a limited increase in viscosity of the micellar solution, the dissolution rate of benzoic acid is increased to a maximum rate and is related to the total solubility as depicted by the Noyes‐Whitney relation. At concentrations of polysorbate 80 exceeding the concentration corresponding to the maximum dissolution rate, the dissolution rate is decreased as the concentration of the surfactant is increased. Because the dissolution rate is inversely proportional to the viscosity, high concentrations of polysorbate 80 increase the viscosity of the micellar solutions to the extent that the dissolution rate is slowed although the total solubility is greatly increased. In micellar solutions maintained at a constant viscosity, the total solubility of benzoic acid increases linearly as the concentration of the surfactant is increased. The dissolution rate of benzoic acid in micellar solutions with a constant viscosity increases progressively without a maximum rate as the concentration of the surfactant is increased.