Elevated plasma levels of oxidized low-density lipoprotein relate to the presence of angiographically detected complex and thrombotic coronary artery lesion morphology in patients with unstable angina.
Elevated plasma levels of oxidized low-density lipoprotein relate to the presence of angiographically detected complex and thrombotic coronary artery lesion morphology in patients with unstable angina.
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DOI：
10.1253/circj.71.681
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发表时间：
2007-04
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通讯作者：
H. Yamashita;S. Ehara;M. Yoshiyama;T. Naruko;K. Haze;N. Shirai;Y. Sugama;Y. Ikura;M. Ohsawa;H. Itabe;T. Kataoka;Yoshiki Kobayashi;A. Becker;J. Yoshikawa;M. Ueda
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作者：
H. Yamashita;S. Ehara;M. Yoshiyama;T. Naruko;K. Haze;N. Shirai;Y. Sugama;Y. Ikura;M. Ohsawa;H. Itabe;T. Kataoka;Yoshiki Kobayashi;A. Becker;J. Yoshikawa;M. Ueda
氧化低密度脂蛋白（ox-LDL）水平升高与斑块不稳定性有关，因此本研究的目的是探讨不稳定型心绞痛（UAP）患者冠状动脉造影斑块形态与ox-LDL水平之间是否存在关系。方法和结果采用高灵敏度酶联免疫吸附法测定了149例不稳定型心绞痛患者和88例正常对照者的血浆ox-LDL水平。罪犯病变的血管造影形态根据Ambrose分类分为简单或复杂。Braunwald III级患者的血浆ox-LDL水平显著高于I级患者（p<0.0001）或对照组（p<0.0001）。在3个Braunwald分类中，复杂病变患者的血浆ox-LDL水平显著高于简单病变患者。多因素Logistic回归分析显示，ox-LDL水平和Braunwald III级是血管造影检测到的复杂病变的独立相关因素。结论在各Braunwald分级的不稳定型心绞痛患者中，血浆ox-LDL水平升高与血管造影检测到的复合物和血栓性病变形态密切相关。
BACKGROUND Increased levels of oxidized low-density lipoprotein (ox-LDL) are related to plaque instability, so the aim of the present study was to investigate whether there is a relationship between angiographic coronary plaque morphology in patients with unstable angina pectoris (UAP) and the level of ox-LDL. METHODS AND RESULTS Plasma ox-LDL levels were measured in 149 patients with UAP and in 88 control subjects, using a highly sensitive enzyme-linked immunosorbent assay method. Angiographic morphology of the culprit lesion was classified as either simple or complex based on the Ambrose classification. Plasma ox-LDL levels in patients with Braunwald class III were significantly higher than in patients with class I (p<0.0001) or in control subjects (p<0.0001). In each of the 3 Braunwald classes, plasma ox-LDL levels in patients with a complex lesion were significantly higher than in patients with a simple lesion. Multivariate logistic regression analysis revealed that ox-LDL level and Braunwald class III were independent factors associated with angiographically detected complex lesions. CONCLUSION In each Braunwald class of UAP, elevated plasma levels of ox-LDL closely relate to the presence of angiographically detected complex and thrombotic lesion morphology.