Automated supramolecular polymerization in a microflow: A versatile platform for multistep supramolecular reactions
Automated supramolecular polymerization in a microflow: A versatile platform for multistep supramolecular reactions
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微流中的自动化超分子聚合：多步超分子反应的多功能平台
作者：
Yamashita;K.; Numata;M.
这项工作报告了一个基本的微流系统能够执行多步超分子聚合。在该体系中，单体的注入、定向超分子共聚、未反应单体的去除和产物超分子二嵌段共聚物的纯化沿三流流程进行。当将超分子聚合物注入三流流的中心流时，超分子聚合总是发生在中心流，两个侧流作为单体的供给和去除线。采用两种苝酰亚胺衍生物作为单体，我们证实了该反应选择性地发生在超分子聚合物的正向端，随着未反应单体的回收，最终得到了高纯度的超分子二嵌段共聚物。双嵌段共聚物是制备多组分超分子嵌段共聚物的基本单元。因此，将目前的系统串联起来，原则上会产生一个能够生产具有所需内部复杂性的超分子聚合物的“微植物”。
This work reports a basic microflow system capable of performing multistep supramolecular polymerization. In this system, injection of the monomer, directional supramolecular copolymerization, removal of the unreacted monomer, and purification of the product supramolecular diblock copolymers are realized along a three‐stream flow. When injecting a supramolecular polymer into the central stream of the three‐stream flow, the supramolecular polymerization always occurs in the central flow, with the two lateral flows serving as supply and removal lines for the monomer. Employing two kinds of perylene bisimide derivatives as monomers, we confirmed that the reaction occurred selectively at the forward‐facing terminus of the supramolecular polymer, along with recovery of the unreacted monomer, ultimately leading to a high‐purity supramolecular diblock copolymer. Diblock copolymers are basic units for preparing multicomponent supramolecular block copolymers. Thus, connecting the present system in series would, in principle, result in a “microplant” capable of producing supramolecular polymers having desired inner complexity.