Marine food pollutants as a risk factor for hypoinsulinemia and type 2 diabetes.
Marine food pollutants as a risk factor for hypoinsulinemia and type 2 diabetes.
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DOI：
10.1097/ede.0b013e318212fab9
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Weihe P
中科院分区：
文献类型：
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作者：
Grandjean P;Henriksen JE;Choi AL;Petersen MS;Dalgård C;Nielsen F;Weihe P
一些持久性环境化学物质被怀疑会增加患2型糖尿病的风险，这是一种在70岁以后特别常见的疾病。在一项针对老年受试者的横断面研究中，研究人员对食物链中高水平海鲜污染物暴露人群进行了研究。对713名70-74岁的法罗群岛居民（占合格人群的64%）进行的临床检查包括空腹血糖和胰岛素浓度以及糖化血红蛋白。通过饮食调查问卷和对血液样本中多氯联苯和相关食物污染物的分析，对领航鲸和其他传统食物中持久性环境化学品的终生暴露进行了估计。患有2型糖尿病或空腹血糖受损的七十岁老人往往有较高的PCB浓度和较高的传统食物摄入量，特别是在儿童和青少年时期。在非糖尿病受试者中，在20岁时调整性别和体重指数后，PCB浓度每增加一倍，空腹胰岛素浓度下降7%（95% CI=-12%至2%）。相反，PCB每增加一倍，空腹血糖浓度增加6%（-1%至13%）。在没有空腹血糖受损的受试者中观察到类似的相关性，而进一步调整当前的体重指数和脂质代谢参数减弱了一些相关性。胰岛素分泌受损似乎是2型糖尿病发病机制的重要组成部分，与持续暴露于亲脂性食物污染物有关。
Some persistent environmental chemicals are suspected of causing an increased risk of type 2 diabetes mellitus, a disease particularly common after age 70. This concern was examined in a cross-sectional study of elderly subjects in a population with elevated contaminant exposures from seafood species high in the food chain. Clinical examinations of 713 Faroese residents aged 70-74 years (64% of eligible population) included fasting plasma concentrations of glucose and insulin, and glycosylated hemoglobin. Lifetime exposure to persistent environmental chemicals from pilot whale and other traditional food was estimated from a dietary questionnaire and by analysis of blood samples for polychlorinated biphenyls (PCBs) and related food contaminants. Septuagenarians with type 2 diabetes or impaired fasting glycemia tended to have higher PCB concentrations and higher past intake of traditional foods, especially during childhood and adolescence. In non-diabetic subjects, the fasting insulin concentration decreased by 7% (95% CI= −12% to −2%) for each doubling of the PCB concentration after adjustment for sex and body mass index at age 20. Conversely, the fasting glucose concentration increased by 6% (−1% to 13%) for each doubling in PCB. Similar associations were seen in subjects without impaired fasting glycemia, while further adjustment for current body mass index and lipid metabolism parameters attenuated some of the associations. Impaired insulin secretion appears to constitute an important part of the type 2 diabetes pathogenesis associated with exposure to persistent lipophilic food contaminants.