Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions.
Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions.
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DOI：
10.1016/j.exger.2023.112105
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发表时间：
2023-03
影响因子：
3.9
通讯作者：
Clayton ZS
中科院分区：
文献类型：
--
作者：
Murray KO;Mahoney SA;Venkatasubramanian R;Seals DR;Clayton ZS
心血管疾病相关的心血管（CV）功能障碍，即动脉功能障碍，是CV疾病（CVD）发展的关键前提。随着年龄的增长，动脉功能障碍的特征是血管内皮功能受损和大弹性动脉硬化，每一个都是CVD的独立预测因素。这些过程在很大程度上是由活性氧（ROS）的过量产生和慢性低度炎症的增加介导的，慢性低度炎症最终导致血管舒张分子一氧化氮的生物利用度降低。此外，还有其他基本的衰老机制，可能会导致过度的ROS和炎症，称为“衰老的标志”），这些动脉功能障碍的其他机制可能代表了随着衰老改善CV健康的治疗靶点。有氧运动是预防和治疗衰老对心血管功能障碍影响的最知名和最有效的干预措施。然而，由于有氧运动的传统障碍，大多数中年和老年人（ML/O）成年人不符合推荐的运动指南，例如减少休闲时间，动机或使用健身设施。因此，开发和实施时间和资源有效的有氧运动替代策略以减轻ML/O成人的CVD负担是生物医学研究的优先事项。模仿有氧运动或受其启发的替代策略，针对衰老基本机制的特定途径，代表了实现这一目标的有希望的方法。
Age-associated cardiovascular (CV) dysfunction, namely arterial dysfunction, is a key antecedent to the development of CV disease (CVD). Arterial dysfunction with aging is characterized by impaired vascular endothelial function and stiffening of the large elastic arteries, each of which is an independent predictor of CVD. These processes are largely mediated by an excess production of reactive oxygen species (ROS) and an increase in chronic, low-grade inflammation that ultimately leads to a reduction in bioavailability of the vasodilatory molecule nitric oxide. Additionally, there are other fundamental aging mechanisms that may contribute to excessive ROS and inflammation termed the “hallmarks of aging”) these additional mechanisms of arterial dysfunction may represent therapeutic targets for improving CV health with aging. Aerobic exercise is the most well-known and effective intervention to prevent and treat the effects of aging on CV dysfunction. However, the majority of mid-life and older (ML/O) adults do not meet recommended exercise guidelines due to traditional barriers to aerobic exercise, such as reduced leisure time, motivation, or access to fitness facilities. Therefore, it is a biomedical research priority to develop and implement time- and resource-efficient alternative strategies to aerobic exercise to reduce the burden of CVD in ML/O adults. Alternative strategies that mimic or are inspired by aerobic exercise, that target pathways specific to the fundamental mechanisms of aging, represent a promising approach to accomplish this goal.
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影响因子：
20.1
作者：
Dai DF;Rabinovitch PS;Ungvari Z
通讯作者：
Ungvari Z
影响因子：
5.7
作者：
通讯作者：
--
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
影响因子：
3.9
作者：
Craighead, Daniel H.;Freeberg, Kaitlin A.;McCarty, Narissa P.;Seals, Douglas R.
通讯作者：
Seals, Douglas R.
DOI：
10.1152/ajpheart.01054.2005
发表时间：
2006-04-01
影响因子：
4.8
作者：
Cook, JN;DeVan, AE;Tanaka, H
通讯作者：
Tanaka, H