Hox genes in normal and neoplastic mouse mammary gland.
Hox genes in normal and neoplastic mouse mammary gland.
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发表时间：
1994-11
期刊：
影响因子：
11.2
通讯作者：
Y. Friedmann;Carla Daniel;P. Strickland;C. Daniel
中科院分区：
文献类型：
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作者：
Y. Friedmann;Carla Daniel;P. Strickland;C. Daniel
含有同源框的基因调节胚胎发育程序，并在某些成人组织和癌症中表达。目前还没有乳房表达的报道。我们从小鼠乳腺中扩增同源框互补DNA，并发现四个主要Hox基因簇的成员表达。更深入地研究了两个Hox基因的表达调控。Hoxc-6转录本存在于青春期和成熟小鼠的腺体中，并在妊娠期间减少。卵巢切除术后水平大幅增加，表明可能是类固醇激素的负调节。Hox的表达在乳腺腺癌和良性移植系中进行了研究，癌前组织从癌症产生。Hoxc-6在癌前组织中低水平表达，但在癌症中不表达。相反，Hoxa-1仅在癌症中表达，而不在正常腺体或癌前乳腺组织中表达，这表明Hox基因可能在乳腺恶性肿瘤逐步发展的晚期阶段发挥作用。
Homeobox-containing genes regulate embryonic developmental programs and are expressed in certain adult tissues and cancers. There has been no report of expression in the breast. We amplified homeobox complementary DNA from mouse mammary gland and found expression of members from each of the four major Hox gene clusters. The regulation of expression of two Hox genes was examined in greater depth. Hoxc-6 transcripts were present in the glands of pubescent and mature mice and decreased during pregnancy. Levels were increased substantially following ovariectomy, indicating possible negative regulation by steroid hormones. Hox expression was studied in mammary adenocarcinomas and in transplant lines of the benign, precancerous tissues from which the cancers arose. Hoxc-6 was expressed at low levels in the precancerous tissue but was not expressed in cancers. In contrast, Hoxa-1 was expressed only in cancers, not in normal gland or in precancerous mammary tissues, suggesting that Hox genes may play a role in a late stage in the stepwise development of mammary malignancies.