Host-mediated inflammation disrupts the intestinal microbiota and promotes the Overgrowth of Enterobacteriaceae
Host-mediated inflammation disrupts the intestinal microbiota and promotes the Overgrowth of Enterobacteriaceae
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DOI：
10.1016/j.chom.2007.06.010
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发表时间：
2007-08-01
影响因子：
30.3
通讯作者：
Finlay, B. Brett
中科院分区：
文献类型：
--
作者：
Lupp, Claudia;Robertson, Marilyn L.;Finlay, B. Brett
虽然正常微生物群被认为是抵抗入侵病原体的关键防御，但肠道病原性感染和宿主炎症对肠道微生物群落的影响尚未阐明。使用小鼠模型的啮齿类柠檬酸杆菌，它密切模仿人类肠道病原体诱导宿主肠道炎症，和空肠柠檬酸杆菌感染，以及化学和遗传诱导的肠道炎症模型，我们证明，响应于感染剂，化学触发，或遗传易感性的宿主介导的炎症显着改变结肠微生物群落。在消除一部分固有微生物群的同时，宿主介导的炎症支持了常驻或引入的需氧细菌的生长，特别是肠杆菌科。此外，肠道病原体的攻击和宿主介导的炎症相结合，显着减少了常驻结肠细菌的总数。这些发现强调了肠道微生物生态系统在感染性结肠炎和非感染性肠道炎症条件（如炎症性肠病）中的重要性。
While the normal microbiota has been implicated as a critical defense against invading pathogens, the impact of enteropathogenic infection and host inflammation on intestinal microbial communities has not been elucidated. Using mouse models of Citrobacter rodentium, which closely mimics human diarrheal pathogens inducing host intestinal inflammation, and Citrobacterjejuni infection, as well as chemically and genetically induced models of intestinal inflammation, we demonstrate that host-mediated inflammation in response to an infecting agent, a chemical trigger, or genetic predisposition markedly alters the colonic microbial community. While eliminating a subset of indigenous microbiota, host-mediated inflammation supported the growth of either the resident or introduced aerobic bacteria, particularly of the Enterobacteriaceae family. Further, assault by an enteropathogen and host-mediated inflammation combined to significantly reduce the total numbers of resident colonic bacteria. These findings underscore the importance of intestinal microbial ecosystems in infectious colitis and noninfectious intestinal inflammatory conditions, such as inflammatory bowel disease.