Place-Related Neuronal Activity in the Monkey Parahippocampal Gyrus and Hippocampal Formation During Virtual Navigation
Place-Related Neuronal Activity in the Monkey Parahippocampal Gyrus and Hippocampal Formation During Virtual Navigation
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DOI：
10.1002/hipo.22209
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发表时间：
2014-01-01
期刊：
影响因子：
3.5
通讯作者：
Nishijo, Hisao
中科院分区：
文献类型：
--
作者：
Furuya, Yoichi;Matsumoto, Jumpei;Nishijo, Hisao
灵长类动物的神经心理学数据表明，海马体结构(HF)和海马旁回(PH)在导航和情景记忆中起着关键作用。为了研究灵长类动物HF和PH神经元在环境适应中的作用，我们记录了猴子在虚拟导航(VN)和指针移位(PT)任务中HF和PH神经元的活动。这些猴子必须用相同的空间线索在三个不同大小的虚拟空间中导航(VN任务)，或者通过操纵操纵杆在屏幕上移动指针(PT任务)以获得奖励。在234个被记录的神经元中，170个和61个神经元分别在VN和PT任务中表现出位置相关活动。在HF和PH神经元之间观察到明显的差异。PH组两个不同虚拟空间的位置场的空间相似性低于HF组，而对远端空间线索反应的特异性则高于HF组。空间视觉信息主要在后部PH中被加工。在缩小的虚拟空间中，HF和PH神经元的空间尺度(位置场大小)减小，如啮齿动物位置细胞所示。这些结果表明，在导航过程中，HF(地标的同心表示)和PH(地标的空间布局表示)在位置识别中的互补作用。(C)2013年威利期刊公司。
Neuropsychological data in primates demonstrated a pivotal role of the hippocampal formation (HF) and parahippocampal gyrus (PH) in navigation and episodic memory. To investigate the role of HF and PH neurons in environmental scaling in primates, we recorded neuronal activities in the monkey HF and PH during virtual navigation (VN) and pointer translocation (PT) tasks. The monkeys had to navigate within three differently sized virtual spaces with the same spatial cues (VN task) or move a pointer on a screen (PT task) by manipulating a joystick to receive a reward. Of the 234 recorded neurons, 170 and 61 neurons displayed place-related activities in the VN and PT tasks, respectively. Significant differences were observed between the HF and PH neurons. The spatial similarity of place fields between the two different virtual spaces was lower in PH than in HF, while specificities of the neuronal responses to distal spatial cues were higher in PH than in HF. Spatial view information was predominately processed in posterior PH. The spatial scales (place field sizes) of the HF and PH neurons were reduced in the reduced virtual space, as shown in rodent place cells. These results suggest the complementary roles of HF (allocentric representation of landmarks) and PH (representation of the spatial layout of landmarks) in the recognition of a location during navigation. (c) 2013 Wiley Periodicals, Inc.