Hantaan Virus RNA Load in Patients Having Hemorrhagic Fever With Renal Syndrome: Correlation With Disease Severity
Hantaan Virus RNA Load in Patients Having Hemorrhagic Fever With Renal Syndrome: Correlation With Disease Severity
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DOI：
10.1093/infdis/jis475
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发表时间：
2013-05-01
影响因子：
6.4
通讯作者：
Jin, Boquan
中科院分区：
文献类型：
--
作者：
Yi, Jing;Xu, Zhuwei;Jin, Boquan
为探讨病毒载量在肾综合征出血热发病中的作用，对101例患者血浆汉滩病毒RNA载量进行定量分析，并分析病毒载量与病程、严重程度、特异性体液免疫水平的关系。79例患者检测到的病毒载量范围为3.43至7.33 log（10）拷贝/mL血浆。在疾病早期，重/危重组患者的病毒载量高于轻/中度组（5.90 vs 5.03 log10 copies/mL; P =.001），提示汉滩病毒载量与疾病严重程度之间存在关联。
To investigate the role of viral load in the pathogenesis of hemorrhagic fever with renal syndrome, the Hantaan virus RNA load in plasma from 101 patients was quantified, and the relationships between viral load and disease course, severity, and level of specific humoral immunity were analyzed. The viral load, detectable in 79 patients, ranged from 3.43 to 7.33 log(10) copies/mL of plasma. In the early stage of disease, patients in severe/critical group were found to have higher viral loads than those in the mild/moderate group (5.90 vs 5.03 log10 copies/mL; P =.001), suggesting an association between Hantaan virus load and disease severity.