Genetic variants in XDH are associated with prognosis for gastric cancer in a Chinese population
Genetic variants in XDH are associated with prognosis for gastric cancer in a Chinese population
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XDH 的遗传变异与中国人群胃癌的预后相关
DOI：
10.1016/j.gene.2018.03.043
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发表时间：
2018-07-15
期刊：
影响因子：
3.5
通讯作者：
Zhang, Zhengdong
中科院分区：
文献类型：
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作者：
Liu, Hanting;Zhu, Haixia;Zhang, Zhengdong
目的：探讨黄嘌呤脱氢酶（XDH）单核苷酸多态性rs207454和rs494852与胃癌（GC）生存的关系。方法：选取940例胃癌患者，采用TaqMan等位基因鉴别法进行基因分型。Kaplan Meier检验和log-rank检验用于评估遗传变异的影响。结果：rs207454 CC基因型患者比AA基因型患者生存时间更长（P = 0.042）。隐性模型中也存在类似的相关性（P = 0.017）。我们进行了表达数量性状位点（eQTL）分析，发现携带rs207454 CC基因型的胃癌患者的XDH水平明显低于携带AA/AC基因型的胃癌患者，提示rs207454多态性影响了XDH的表达。此外，Kaplan-Meier曲线显示，高表达的XDH胃癌患者的生存结局明显差于低表达的患者（风险比[HR] = 1.53, 95%可信区间[CI] = 1.29-1.82）。结论：XDH基因变异与胃癌生存相关，可作为胃癌患者的预后指标。
Objective: We explored the association between single nucleotide polymorphisms (SNPs) rs207454 and rs494852 located in xanthine dehydrogenase (XDH) and gastric cancer (GC) survival.Methods: A total of 940 patients with gastric cancer were enrolled and genotyped using TaqMan allelic discrimination method. The Kaplan Meier test and log-rank examine were used to assess the effect of genetic variation.Results: Patients carrying rs207454 CC genotype had a longer survival time than those with the AA genotype (P = 0.042). The similar association was detected in the recessive model (P = 0.017). We conducted expression quantitative trait loci (eQTL) analysis and found that gastric cancer patients carrying rs207454 CC genotype had significant lower XDH levels than those with AA/AC genotype, suggesting that rs207454 polymorphism effected the expression of XDH. Additionally, the Kaplan-Meier curves showed that gastric cancer patients with high expression of XDH had remarkably poor survival outcome than those with low expression (hazard ratio [HR] = 1.53, 95% confidence interval [CI] = 1.29-1.82).Conclusions: Genetic variants in XDH were associated with the survival of gastric cancer and may act as prognostic markers for individual suffered from gastric cancer.