A new magnetic nanocapsule containing 5-fluorouracil: In vivo drug release, anti-tumor, and pro-apoptotic effects on CT26 cells allograft model
A new magnetic nanocapsule containing 5-fluorouracil: In vivo drug release, anti-tumor, and pro-apoptotic effects on CT26 cells allograft model
复制标题
DOI：
10.1177/0885328214536940
复制
发表时间：
2014-10-01
影响因子：
2.9
通讯作者：
Khoei, Samideh
中科院分区：
文献类型：
--
作者：
Shakeri-Zadeh, Ali;Shiran, Mohammad-Bagher;Khoei, Samideh
The purpose of this study was to create an optimized method for preparation of 5-fluorouracil-loaded magnetic poly lactic-co-glycolic acid nanocapsules and to investigate its potential as multifunctional carriers to deliver therapeutic agents for tumor-targeted therapies. The invitro release of the newly synthesized 5-fluorouracil-loaded poly lactic-co-glycolic acid magnetic nanocapsules was investigated in phosphate-buffered saline medium using the dialysis method. Invivo release studies of the magnetic nanocapsules were performed in rabbits. Finally, the targeting properties, anti-tumor, and pro-apoptotic effects of this new magnetic nanocapsule on CT26 cells allograft model were studied. The effective diameter of nanocapsules was 67.2nm. Invivo release investigations showed that 5-fluorouracil has a sustained release profile, prolonged lifetime in the rabbit plasma, and increased tissue appetency when loaded into the magnetic nanocapsule. Magnetic resonance imaging confirmed that the magnetic nanocapsules were successfully targeted to the tumor. Additionally, the anti-tumor studies revealed that the targeted therapy with magnetic nanocapsules containing 5-fluorouracil effectively inhibits the growth of tumors compared with 5-fluorouracil alone (P
