Molecular Responses of Cancers by Natural Products: Modifications of Autophagy Revealed by Literature Analysis.
Molecular Responses of Cancers by Natural Products: Modifications of Autophagy Revealed by Literature Analysis.
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DOI：
10.1615/critrevoncog.2018027566
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发表时间：
2018
影响因子：
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通讯作者：
Andy Wai Kan Yeung;A. El‐Demerdash;I. Berindan‐Neagoe;A. Atanasov;Y. Ho
中科院分区：
文献类型：
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作者：
Andy Wai Kan Yeung;A. El‐Demerdash;I. Berindan‐Neagoe;A. Atanasov;Y. Ho
虽然许多文献计量学研究已经检查了癌症研究的各个方面，但关注癌症研究中天然产物的科学研究的景观尚未被表征。使用Web of Science Core Collection在线数据库，我们识别和分析了癌症相关研究中天然产物的科学文章。英语是99%文章的出版语言。一般来说，一篇文章的年引用量在发表后迅速增加，在第二年达到一个平台，在这个平台上停留10年，然后开始下降。贡献最大的五个期刊类别是药物化学，贡献最多，有1890篇文章（8012篇文章的24%）;肿瘤学（20%，有1572篇文章）;药理学和药学（19%，有1557篇文章）;生物化学和分子生物学（15%，有1225篇文章）;植物科学（11%，有883篇文章）。美国和西班牙产生了大量的高平均引用的文章，中国自2009年以来一直在增加。细胞凋亡和细胞毒性是两个最常用的关键词。在69篇出版物中提到了天然产物对与癌症相关的自噬的影响。我们的文献分析揭示了一个动态变化的景观和越来越多的研究调查，重点是在癌症的背景下研究天然产物。姜黄素、类黄酮和白藜芦醇是最常提到的天然产物。乳腺癌、前列腺癌和结肠癌是最常提及的癌症。
Although numerous bibliometric studies have examined various aspects of cancer research, the landscape of scientific studies focusing on natural products in cancer research has not been characterized. Using the Web of Science Core Collection online database, we identify and analyze scientific articles on natural products in cancer-related research. English is the language of publication for 99% of articles. In general, annual citation count of an article increases quickly after publication, reaches a plateau in the second year, stays in this plateau for 10 yr, and then begins to fall. The five most contributing journal categories are medicinal chemistry, contributing the most at 1890 articles (24% of 8012 articles); oncology (20%, with 1572 articles); pharmacology and pharmacy (19%, with 1557); biochemistry and molecular biology (15%, with 1225); and plant sciences (11%, with 883 articles). The United States and Spain yield a larger number of articles with high average citations, and China has been increasing since 2009. Apoptosis and cytotoxicity are the two most-frequently used keywords. Effects of natural products on autophagy with a relevance to cancer are mentioned in 69 publications. Our literature analysis reveals a dynamically evolving landscape and an increasing volume of research investigations that are focused on the study of natural products in the context of cancer. Curcumin, flavonoids, and resveratrol are the most-frequently mentioned natural products. Cancer of the breast, prostate, and colon are the most-frequently mentioned cancers.