Arabidopsis transcription factors:: Genome-wide comparative analysis among eukaryotes
Arabidopsis transcription factors:: Genome-wide comparative analysis among eukaryotes
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DOI：
10.1126/science.290.5499.2105
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发表时间：
2000-12-15
期刊：
影响因子：
56.9
通讯作者：
Yu, CL
中科院分区：
文献类型：
--
作者：
Riechmann, JL;Heard, J;Yu, CL
拟南芥基因组序列的完成允许对真核生物三个王国的转录调节因子进行比较分析。拟南芥基因组的5%以上编码超过1500种转录因子，其中约45%来自植物特异性家族。拟南芥转录因子属于所有真核生物共有的家族，除了保守的DNA结合结构域之外，与其他界的转录因子没有显著的相似性，其中许多转录因子以特定于每个谱系的组合排列。全基因组的比较揭示了转录调控多样性的进化过程。
The completion of the Arabidopsis thaliana genome sequence allows a comparative analysis of transcriptional regulators across the three eukaryotic kingdoms. Arabidopsis dedicates over 5% of its genome to code for more than 1500 transcription factors, about 45% of which are from families specific to plants. Arabidopsis transcription factors that belong to families common to all eukaryotes do not share significant similarity with those of the other kingdoms beyond the conserved DNA binding domains, many of which have been arranged in combinations specific to each lineage. The genome-wide comparison reveals the evolutionary generation of diversity in the regulation of transcription.