The Importance of Dendritic Cells in Maintaining Immune Tolerance.
The Importance of Dendritic Cells in Maintaining Immune Tolerance.
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DOI：
10.4049/jimmunol.1601629
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发表时间：
2017-03-15
期刊：
影响因子：
--
通讯作者：
Lesage S
中科院分区：
文献类型：
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作者：
Audiger C;Rahman MJ;Yun TJ;Tarbell KV;Lesage S
免疫耐受是防止免疫系统对自身产生反应，从而避免自身免疫性疾病发展所必需的。在这里，我们回顾了将树突状细胞(DC)定位为胸腺和外周免疫耐受的关键调节器的关键发现。虽然DC对诱导免疫和耐受都很重要，但自身免疫力的增强与DC的减少相关联，表明它们在耐受诱导中没有多余的作用。DC介导的T细胞免疫耐受是一个活跃的过程，受遗传变异、环境信号以及呈递抗原给T细胞的特定DC亚群的性质的影响。回答关于DC在免疫耐受中的作用的许多悬而未决的问题可能会导致开发预防自身免疫性疾病的新疗法。
Immune tolerance is necessary to prevent the immune system from reacting against self, and thus to avoid the development of autoimmune diseases. Here, we review key findings that position dendritic cells (DCs) as critical modulators of both thymic and peripheral immune tolerance. Although DCs are important for inducing both immunity and tolerance, increased autoimmunity associated with decreased DCs suggests their non-redundant role in tolerance induction. DC-mediated T cell immune tolerance is an active process that is influenced by genetic variants, environmental signals as well as the nature of the specific DC subset presenting antigen to T cells. Answering the many open questions with regards to the role of DC in immune tolerance could lead to the development of novel therapies for the prevention of autoimmune diseases.