Supranigral injection of neuregulin1-beta induces striatal dopamine overflow.
Supranigral injection of neuregulin1-beta induces striatal dopamine overflow.
复制标题
黑猩猩上注射神经调节蛋白1-β可诱导纹状体多巴胺溢出。
DOI：
10.1016/j.brainres.2004.08.066
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Seroogy,KimB
中科院分区：
文献类型：
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作者：
Yurek,DavidM;Zhang,Lixin;Fletcher-Turner,Anita;Seroogy,KimB
先前的研究提供了解剖学证据，功能性神经调节蛋白受体ErbB 4存在于腹侧中脑内，在那里它与黑质和腹侧被盖区的多巴胺神经元共定位。在这项研究中，我们提供的证据表明，neuregulin 1-β（a.k.a. heregulin 1-β），一种优先结合并激活ErbB 4受体的神经调节蛋白-1基因同种型，当注射到同侧黑质背侧的区域时，几乎立即引起纹状体多巴胺的溢出。这些数据表明，neuregulins可以调节中纹状体多巴胺能神经元的活性。
Previous studies have provided anatomical evidence that the functional neuregulin receptor, ErbB4, is present within the ventral midbrain where it is co-localized to dopamine neurons of the substantia nigra and ventral tegmental area. In this study, we provide evidence that neuregulin1-β (a.k.a. heregulin1-β), a neuregulin-1 gene isoform that preferentially binds to and activates the ErbB4 receptor, evokes an almost immediate overflow of striatal dopamine when injected into a region just dorsal to the ipsilateral substantia nigra. These data are indicative that neuregulins can modulate the activity of mesostriatal dopaminergic neurons.