The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target
The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target
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DOI：
10.1038/sj.bjc.6602329
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发表时间：
2005-01-31
影响因子：
8.8
通讯作者：
Mukai, K
中科院分区：
文献类型：
--
作者：
Kuroda, M;Kiyono, T;Mukai, K
在这里，我们表明，人乳头瘤病毒（HPV）E6和E7癌蛋白诱导hWAPL表达。此外，hWAPL的小干扰RNA（siRNA）抑制裸鼠中源自SiHa细胞的肿瘤的生长。hWAPL可能是宫颈癌治疗的有效靶点之一。
Here we show that human papillomavirus ( HPV) E6 and E7 oncoproteins induce hWAPL expression. In addition, small interfering RNA ( siRNA) of hWAPL suppressed the growth of tumours derived from SiHa cells in nude mice. Thus, hWAPL may be one of the effective targets of uterine cervical cancer therapy.