Association of parvoviruses with rheumatoid arthritis of humans.
Association of parvoviruses with rheumatoid arthritis of humans.
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细小病毒与人类类风湿性关节炎的关联。
DOI：
10.1126/science.6701529
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Boyd,RJ
中科院分区：
文献类型：
--
作者：
Simpson,RW;McGinty,L;Simon,L;Smith,CA;Godzeski,CW;Boyd,RJ
从一名严重类风湿性关节炎患者的滑膜组织中分离到一种形态和理化性质类似细小病毒的小病毒。这种病毒，命名为RA-1，在新生小鼠中引发一种综合征，包括神经紊乱、肢体永久性瘫痪、侏儒症、脱发、睑缘炎、“掩蔽”和胸椎僵硬弯曲。针对RA-1的多克隆抗体显示出高的病毒中和活性，并且在免疫测定中检测到来自不同类风湿性关节炎患者但不具有骨关节炎的人的滑膜细胞中的反应性抗原。从其他几个类风湿性关节炎患者中分离出的细小病毒对新生小鼠的致病性很弱，但可以在这些动物的组织中产生RA-1病毒特异性抗原。尚未确定RA-1和哺乳动物物种的现有细小病毒相关。
A small virus resembling parvoviruses in its morphological and physicochemical properties was derived from synovial tissue of a patient with severe rheumatoid arthritis. This virus, designated RA-1, elicits a syndrome in neonatal mice that includes neurological disturbances, permanent crippling of limbs, dwarfism, alopecia, blepharitis, "masking," and a rigid curvature of the thoracic spine. Polyclonal antibodies against RA-1 display high virus neutralizing activity and in immunoassays detect reactive antigen in synovial cells from different rheumatoid arthritis patients but not persons with osteoarthritis. Putative parvoviruses isolated from several other rheumatoid arthritis patients are only weakly pathogenic for newborn mice but can generate RA-1 virus-specific antigens in tissues of these animals. It has not been established that RA-1 and existing parvoviruses of mammalian species are related.