Characterization of macroporous carbonate-substituted hydroxyapatite bodies prepared in different phosphate solutions
Characterization of macroporous carbonate-substituted hydroxyapatite bodies prepared in different phosphate solutions
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DOI：
10.1007/s10853-007-1629-3
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发表时间：
2007-09-01
影响因子：
4.5
通讯作者：
Ishikawa, Kunio
中科院分区：
文献类型：
--
作者：
Lee, Yoong;Hahm, Yeong Min;Ishikawa, Kunio
人体骨矿物质与化学计量羟基磷灰石(Ca-10 (PO4)(6)（OH)(2)）的组成不同，它含有额外的离子，其中CO3 -是最丰富的种类。以高孔碳酸钙（CaCO3）为原料，在1M M2HPO4和M3PO4溶液（M = NH4或K）中，在120℃下进行水热处理，制备了碳酸取代羟基磷灰石（CHA）体。结果表明，无论何种磷酸盐溶液，水热处理24 h后，CaCO3体几乎转化为CHA体。但在K3PO4中处理48 h后，仍有少量CaCO3残留。除K2HPO4外，在这些溶液中制备的CHA体均呈片状，与制备CHA体所用的原始CaCO3体呈棒状不同。在K2HPO4中制备的CHA呈球状晶体。CHA体的平均孔径和孔洞尺寸分别为150 μ m和70 μ m，与溶液无关，其孔隙率均在89%左右。磷酸钾溶液得到的CHA体中碳酸盐含量略高于磷酸铵溶液得到的CHA体。在磷酸钾溶液中进行水热处理后，得到的羧酸多为b型。另一方面，在磷酸铵溶液中得到混合的a型和b型CHA（摩尔比约为1-2）。CHA体内co3.2含量与磷酸盐溶液类型有关，在磷酸钾溶液中略高。
Bone mineral of human is different in composition from the stoichiometric hydroxyapatite (Ca-10 (PO4)(6)(OH)(2)) in that it contains additional ions, of which CO3 2-is the most abundant species. Carbonate-substituted hydroxyapatite (CHA) bodies were prepared by the hydrothermal treatment of highly porous calcium carbonate (CaCO3) body at 120 degrees C in 1M M2HPO4 and M3PO4 solutions (M = NH4 or K). It was found that CaCO3 body was almost transformed into CHA body after hydrothermal treatment for 24 h irrespective of type of phosphate solution. However, a small amount of CaCO3 still remained after the treatment in K3PO4 for 48 h. Crystal shape of CHA bodies prepared in those solutions except for K2HPO4 was flake-like, which was different from that (stick-like) of original CaCO3 body used for the preparation of CHA body. CHA prepared in the K2HPO4 showed globule-like crystal. Average pore size and hole size of the CHA bodies were 150, 70 mu m and their porosities were about 89% irrespective of the solution. Carbonate content was slightly higher in the CHA bodies obtained from potassium phosphate solutions than in those obtained from ammonium phosphate solutions. Mostly B-type CHA was obtained after the hydrothermal treatment in the potassium phosphate solutions. On the other hand, mixed A-and B-type CHA (ca. 1-2 in molar ratio) was obtained in the ammonium phosphate solutions. The content of CO3 2-in the CHA body depended on the type of phosphate solution and was slightly larger in the potassium phosphate solutions.