Apoptosis in human uterine leiomyomas.
Apoptosis in human uterine leiomyomas.
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DOI：
10.1055/s-2004-828615
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发表时间：
2004-05
影响因子：
2.7
通讯作者：
Kristina M Martel;A. C. Ko;G. Christman;J. M. Stribley
中科院分区：
文献类型：
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作者：
Kristina M Martel;A. C. Ko;G. Christman;J. M. Stribley
人类子宫平滑肌瘤（肌瘤）是良性肿瘤，通常发生在育龄和围绝经期妇女。这些肿瘤对世界各地的许多妇女造成了严重和昂贵的健康问题。替代疗法很少，子宫切除术是许多医生选择的治疗方法。越来越多的证据表明，平滑肌瘤的发展可能受到多种因素的影响，包括遗传、环境和激素的影响，导致任何数量的凋亡途径可能失败。了解细胞凋亡在新生子宫肌瘤组织正常消退中的作用，以及这种失败如何影响平滑肌瘤肿瘤的生长，可能有助于更好地理解如何开发有效且侵入性较小的治疗方法。下面的综述试图强调目前已知的平滑肌瘤细胞凋亡与正常肌层的比较，以及未来需要研究的地方。
Human uterine leiomyomas (fibroids) are benign neoplasms that typically occur in reproductive age and perimenopausal women. These tumors pose a significant and costly health concern for numerous women throughout the world. Alternative therapies are few, with hysterectomy being the treatment of choice by many physicians. There is a growing body of evidence suggesting that the development of leiomyomas may be influenced by numerous factors including genetic, environmental, and hormonal influences resulting in a possible failure of any number of apoptotic pathways. Understanding the role apoptosis plays in the normal regression of nascent myometrial tissue and how this failure may influence leiomyoma tumor growth may provide a better understanding of how to develop effective and less invasive treatment modalities for this disease. The following review attempts to highlight what is currently known about apoptosis in leiomyomas as compared with the normal myometrium and where future research is needed.