Identification of a prognostic signature of nine metabolism-related genes for hepatocellular carcinoma
Identification of a prognostic signature of nine metabolism-related genes for hepatocellular carcinoma
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DOI：
10.7717/peerj.9774
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发表时间：
2020-09-01
期刊：
影响因子：
2.7
通讯作者：
Liu, Zhengchun
中科院分区：
文献类型：
--
作者：
Tang, Chaozhi;Ma, Jiakang;Liu, Zhengchun
背景。肝细胞癌（HCC）是第五大常见癌症。由于肝脏代谢的变化有助于肝脏疾病的发展，因此有必要建立HCC代谢相关的预后模型。我们构建了一个包含九个基因的代谢相关基因 (MRG) 特征，将 HCC 患者分为高风险组和低风险组。结果。癌症基因组图谱（TCGA）队列中低风险组患者的生存率（总生存期：OS、无复发生存期和无进展生存期）显着高于高风险组患者。 OS 预后特征在国际癌症基因组联盟独立队列中得到验证。该模型相应的受试者工作特征曲线表明，该特征在 1、3 和 5 年的 OS 改善方面具有良好的诊断效率。分层分析表明，MRG 特征与男性患者、老年患者的更好预后显着相关
Background. Hepatocellular carcinoma (HCC) is the fifth most common cancer. Since changes in liver metabolism contribute to liver disease development, it is necessary to build a metabolism-related prognostic model for HCC.Methods. We constructed a metabolism-related-gene (MRG) signature comprising nine genes, which segregated HCC patients into high- and low-risk groups.Results. The survival rate (overall survival: OS; relapse-free survival; and progression-free survival) of patients in the low-risk group of The Cancer Genome Atlas (TCGA) cohort was significantly higher than that of patients in the high-risk group. The OS prognostic signature was validated in the International Cancer Genome Consortium independent cohort. The corresponding receiver operating characteristic curves of the model indicated that the signature had good diagnostic efficiency, in terms of improving OS over 1, 3, and 5 years. Hierarchical analysis demonstrated that the MRG signature was significantly associated with better prognosis in male patients, patients aged