The apolipoprotein B concentration in gingival crevicular fluid increases in patients with diabetes mellitus.
The apolipoprotein B concentration in gingival crevicular fluid increases in patients with diabetes mellitus.
复制标题
糖尿病患者龈沟液中载脂蛋白 B 浓度升高。
DOI：
10.1016/j.clinbiochem.2013.09.016
复制
发表时间：
2014
影响因子：
2.8
通讯作者：
Yamamoto M.
中科院分区：
文献类型：
--
作者：
Noguchi E;Kato R;Ohno K;Mitsui A;Obama T;Hirano T;Itabe H;Yamamoto M.
口腔健康状况与糖尿病（DM）和血脂异常有着密切的关系。本研究检测了18例糖尿病患者和18例健康对照者龈沟液（GCF）中载脂蛋白B（apoB）和氧化低密度脂蛋白（oxLDL）的含量。GCF是用纸点收集的，没有造成任何伤害。载脂蛋白B和氧化低密度脂蛋白水平测定夹心ELISA assays.ResultsThe牙齿的数量与深探测口袋深度和牙齿的数量与出血探测，两个典型的牙周参数，与DM参数，如血红蛋白A1C。糖尿病组GCF体积、GCF中蛋白质、apoB和oxLDL浓度均显著高于健康对照组。特别是，载脂蛋白B浓度增加6倍，GCF中的DM患者。GCF载脂蛋白B浓度与DM参数的plasma.ConclusionGCF可以是一个临床来源，不仅检查患者的口腔状态，但也有一定的全身条件。
ObjectiveOral health conditions have a significant relationship with diabetes mellitus (DM) as well as dyslipidemia. In this study, we investigated the levels of apolipoprotein B (apoB) and oxidized low-density lipoprotein (oxLDL) in the gingival crevicular fluid (GCF) from patients with DM.MethodsGCF and blood samples from 18 DM patients and 18 healthy subjects were examined. GCF was collected with paper points without inflicting any harm. The apoB and oxLDL levels were measured by sandwich ELISA assays.ResultsThe number of teeth with a deep probing pocket depth and the number of teeth with bleeding on probing, two typical periodontal parameters, correlated with the DM parameters, such as hemoglobin A1c. The GCF volume and the concentrations of protein, apoB and oxLDL in GCF were significantly higher in the DM patients than in the healthy subjects. In particular, the apoB concentration in GCF was increased 6-fold in the DM patients. The GCF apoB concentration correlated well with the DM parameters in plasma.ConclusionGCF could be a clinical source for examining not only the oral status of patients, but also certain systemic conditions.