Angiogenesis in transgenic models of multistep carcinogenesis
Angiogenesis in transgenic models of multistep carcinogenesis
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DOI：
10.1023/a:1006418723103
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发表时间：
2000-10-01
影响因子：
3.9
通讯作者：
Aguzzi, A
中科院分区：
文献类型：
--
作者：
D'Angelo, MG;Afanasieva, T;Aguzzi, A
人类癌症的组织病理学和流行病学，以及对肿瘤发生的动物模型的研究，已经导致了一个广泛接受的观念，即多种遗传和表观遗传变化必须积累才能发展为恶性肿瘤。除了增殖能力和下调细胞死亡（细胞凋亡）的能力外，新血管的形成（肿瘤血管生成）已被认为是实体瘤在直径约1-2毫米的显微镜下逐渐生长和扩张的必要条件。过度表达癌基因激活形式或携带肿瘤抑制基因靶向突变的小鼠已被证明对将这些基因的功能与特定肿瘤过程联系起来非常有用；这些小鼠的杂交使我们能够研究不同遗传病变在疾病进展中的协同程度，从而更好地理解肿瘤发生的多阶段性质。
The histopathology and the epidemiology of human cancers, as well as studies of animal models of tumorigenesis, have led to a widely accepted notion that multiple genetic and epigenetic changes have to accumulate for progression to malignancy. Formation of new blood vessels (tumor angiogenesis) has been recognized, in addition to proliferative capabilities and to the ability to down-modulate cell death (apoptosis), as essential for the progressive growth and expansion of solid tumors beyond microscopic sizes of about 1-2 mm in diameter. Mice overexpressing activated forms of oncogenes or carrying targeted mutations in tumor suppressor genes have proven extremely useful for to linking the function of these genes with specific tumor processes; the interbreeding of these mice let us study the extent of cooperativity between different genetic lesions in disease progression, leading to a greater understanding of multi-stage nature of tumorigenesis.