Real-time implementation of a dual-mode ultrasound array system: in vivo results.
Real-time implementation of a dual-mode ultrasound array system: in vivo results.
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DOI：
10.1109/tbme.2013.2264484
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发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
Ebbini ES
中科院分区：
文献类型：
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作者：
Casper AJ;Liu D;Ballard JR;Ebbini ES
描述了一种用于成像和治疗的实时双模超声阵列（DMUA）系统。该系统采用凹面（40毫米曲率半径）3.5兆赫，32元阵列和模块化多通道发射器/接收器。它能够在各种成像和治疗模式（发射）下工作，即使在高功率工作期间，也能在所有阵列元件上连续接收。由现场可编程门阵列（FPGA）和图形处理单元（GPU）组成的信号链用于实现实时、软件定义的波束形成和图像形成。成像数据，从质量保证幻影以及在体内的小型和大型动物模型，提出和讨论。使用时间同步和空间对准的诊断探头获得的相应图像证实了DMUA在其几何中心周围的扩展视场（FOV）中形成具有足够对比度的解剖学正确图像的能力。此外，高帧率DMUA数据还证明了在45 - 50 dB动态范围的HIFU暴露期间检测和定位指示空化和/或组织沸腾的回波变化的可行性。研究结果还表明，DMUA的轴向和横向分辨率与其f数和带宽一致，具有良好的散斑盒特性。这些结果指出了一种治疗诊断DMUA系统，该系统能够使用聚焦超声对病变形成具有高度特异性的组织性质变化进行定量成像。
A real-time dual-mode ultrasound array (DMUA) system for imaging and therapy is described. The system utilizes a concave (40-mm radius of curvature) 3.5 MHz, 32 element array and modular multi-channel transmitter/receiver. It is capable of operating in a variety of imaging and therapy modes (on transmit) and continuous receive on all array elements even during high-power operation. A signal chain consisting of field-programmable gate arrays (FPGA) and graphical processing units (GPU) is used to enable real-time, software-defined beamforming and image formation. Imaging data, from quality assurance phantoms as well as in vivo small and large animal models, are presented and discussed. Corresponding images obtained using a temporally-synchronized and spatially-aligned diagnostic probe confirm the DMUA’s ability to form anatomically-correct images with sufficient contrast in an extended field of view (FOV) around its geometric center. In addition, high frame rate DMUA data also demonstrate the feasibility of detection and localization of echo changes indicative of cavitation and/or tissue boiling during HIFU exposures with 45 – 50 dB dynamic range. The results also show that the axial and lateral resolution of the DMUA are consistent with its fnumber and bandwidth with well behaved speckle cell characteristics. These results point the way to a theranostic DMUA system capable of quantitative imaging of tissue property changes with high specificity to lesion formation using focused ultrasound.