A non-major histocompatibility locus determines tissue specificity in the pathogenic process underlying synovial proliferation in a mouse arthropathy model
A non-major histocompatibility locus determines tissue specificity in the pathogenic process underlying synovial proliferation in a mouse arthropathy model
复制标题
非主要组织相容性位点决定小鼠关节病模型中滑膜增殖致病过程的组织特异性
DOI：
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发表时间：
2006
影响因子：
27.4
通讯作者：
M. Ono
中科院分区：
文献类型：
--
作者：
Ming;S. Mori;F. Date;H. Furukawa;M. Ono
背景：报道了两个Fas缺陷品系的特定F1小鼠自发性踝关节僵直的发生率和特点。本文报道了F2代小鼠滑膜增殖和关节僵硬的符合情况。目的：阐明这两种不同的表现在遗传上是否不同。方法：将MRL/Mp、Faslpr-sap-/sap-和C3H/He.Faslpr小鼠杂交，建立关节病组小鼠(MCF2)。6个月龄时麻醉下放血处死小鼠。光镜下观察滑膜增生的病理分级。利用73个微卫星标记对雄性MCF2小鼠进行了全基因组扫描，获得了一个连锁位点。结果：在雄性和雌性MCF2小鼠中均可观察到滑膜增殖。在MCF2小鼠中，滑膜增殖的分级与强直的发生没有相关性。在11号染色体中部有一个可能的感病基因，该基因是一个隐性遗传的MRL等位基因。结论：滑膜增生和关节僵硬的发病机制存在遗传差异。目前的基因座与一些与类风湿性关节炎相关的基因座和其他与实验性关节炎相关的基因座重叠。
Background: The incidence and characteristics of spontaneous ankylosis in the ankle of specific F1 mice descended from two Fas-deficient strains were reported. Here the coincidence of synovial proliferation and ankylosis in the descendent F2 mice is reported. Aim: To clarify whether the two distinct manifestations are genetically different. Methods: An arthropathic group of mice (MCF2) were bred by intercrossing MRL/Mp.Faslpr-sap–/sap– and C3H/He.Faslpr mice. All mice were killed by bleeding under anaesthesia when they were 6 months old. Pathological grades for synovial proliferation were determined by microscopical examination. To obtain a linkage locus, the whole genome of male MCF2 mice was scanned by using 73 microsatellite markers. Results: Synovial proliferation was equally observed in male and female MCF2 mice. No correlation was observed between the grades of synovial proliferation and the ankylosis occurring in the MCF2 mice. A suggestive susceptibility locus was shown in the middle of chromosome 11. This locus was an MRL allele with a recessive inheritance mode. Conclusion: The pathogenic mechanisms of synovial proliferation and ankylosis are genetically different. The present locus is overlapped with some loci associated with rheumatoid arthritis and with others associated with experimental arthritides.
影响因子：
--
作者：
Adarichev, VA;Nesterovitch, AB;Glant, TT
通讯作者：
Glant, TT
影响因子：
6
作者：
Butterfield, RJ;Blankenhorn, EP;Teuscher, G
通讯作者：
Teuscher, G