RNA-Puzzles: A CASP-like evaluation of RNA three-dimensional structure prediction
RNA-Puzzles: A CASP-like evaluation of RNA three-dimensional structure prediction
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DOI：
10.1261/rna.031054.111
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发表时间：
2012-04-01
期刊：
影响因子：
4.5
通讯作者：
Westhof, Eric
中科院分区：
文献类型：
--
作者：
Cruz, Jose Almeida;Blanchet, Marc-Frederick;Westhof, Eric
我们报告的结果的第一个，集体，盲实验在RNA三维（3D）结构预测，包括三个预测难题。目标是评估RNA结构预测技术的前沿;比较现有的方法和工具;并评估它们在序列长度和结构复杂性方面的相对优势，弱点和局限性。这些结果应该让潜在的用户深入了解现有方法对不同应用的适用性，并促进RNA结构预测社区正在进行的改进预测工具的努力。我们还报告了一个自动化评估管道的创建，以促进未来RNA结构预测练习的分析。
We report the results of a first, collective, blind experiment in RNA three-dimensional (3D) structure prediction, encompassing three prediction puzzles. The goals are to assess the leading edge of RNA structure prediction techniques; compare existing methods and tools; and evaluate their relative strengths, weaknesses, and limitations in terms of sequence length and structural complexity. The results should give potential users insight into the suitability of available methods for different applications and facilitate efforts in the RNA structure prediction community in ongoing efforts to improve prediction tools. We also report the creation of an automated evaluation pipeline to facilitate the analysis of future RNA structure prediction exercises.