Assessment of the rapid test based on an immunochromatography technique for detecting anti-Treponema pallidum antibodies
Assessment of the rapid test based on an immunochromatography technique for detecting anti-Treponema pallidum antibodies
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DOI：
10.1590/s0036-46652003000600004
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发表时间：
2003-12-01
期刊：
影响因子：
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通讯作者：
Ueda, Mirthes
中科院分区：
文献类型：
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作者：
Sato, Neuza Satomi;Melo, Carmen Silvia de;Ueda, Mirthes
针对梅毒临床、流行病学和血清学诊断患者、除梅毒以外的性传播疾病患者以及梅毒血清学阴性个体的血清样本，对基于免疫层析测定的DetermineTM Syphilis TP (Abbott Lab.) 检测梅毒螺旋体特异性抗体的快速检测进行了评估。 DefineTM测试的敏感性为93.6%，特异性为92.5%，阳性预测值和阴性预测值分别为95.2%和93.7%。最近患有潜伏梅毒的患者的一份血清样本显示出前带反应。 DefineTM 是一种快速检测、高度特异性且易于执行。该技术消除了对设备的需求，其诊断特征表明，它可以作为某些紧急情况下或居住在偏远地区的患者梅毒筛查的替代检测方法。
A rapid test based on an immunochromatography assay - DetermineTM Syphilis TP (Abbott Lab.) for detecting specific antibodies to Treponema pallidum was evaluated against serum samples from patients with clinical, epidemiological and serological diagnosis of syphilis, patients with sexually transmitted disease other than syphilis, and individuals with negative serology for syphilis. The DetermineTM test presented the sensitivity of 93.6%, specificity of 92.5%, and positive predictive value and negative predictive value of 95.2% and 93.7%, respectively. One serum sample from patient with recent latent syphilis showed a prozone reaction. DetermineTM is a rapid assay, highly specific and easy to perform. This technique obviates the need of equipment and its diagnostic features demonstrate that it may be applicable as an alternative assay for syphilis screening under some emergency conditions or for patients living in remote localities.