Association of Timing and Balance of Physical Activity and Rest/Sleep With Risk of COVID-19: A UK Biobank Study.
Association of Timing and Balance of Physical Activity and Rest/Sleep With Risk of COVID-19: A UK Biobank Study.
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DOI：
10.1016/j.mayocp.2020.10.032
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发表时间：
2021-01
影响因子：
8.9
通讯作者：
Yates T
中科院分区：
文献类型：
--
作者：
Rowlands AV;Kloecker DE;Chudasama Y;Davies MJ;Dawkins NP;Edwardson CL;Gillies C;Khunti K;Razieh C;Islam N;Zaccardi F;Yates T
行为生活方式因素与心脏代谢性疾病和肥胖相关，这些都是冠状病毒病2019年的风险因素(新冠肺炎)。我们的目的是调查体力活动、体力活动和睡眠/休息的时间和平衡是否与SARS-CoV-2阳性和新冠肺炎严重程度相关。数据包括来自91,248名英国生物库参与者的加速度计数据和截至2020年7月19日的完整协变量和链接新冠肺炎数据。用调整后的Logistic回归分析了SARS-CoV-2阳性和新冠肺炎严重程度与总体体力活动、中到剧烈体力活动、活动和睡眠/休息的平衡以及睡眠/休息时间的变异性的关系。在207名检测结果呈阳性的人中，124人被归类为严重感染。总体体力活动和平均动脉压与严重的新冠肺炎无关，而活动和睡眠/休息之间的平衡不良(按标准差计算的优势比[OR]：0.71；95%可信区间[CI]，0.62至0.81])。这一发现与白天活动较多与较低的风险(OR，0.75；95%CI，0.61至0.93)相关，但睡眠/休息期间较多的运动与较高的严重感染风险(OR，1.26；95%CI，1.12至1.42)相关。睡眠/休息时间的较大变异性也与风险增加相关(OR，1.21；95%CI，1.08至1.35)。检测呈阳性的结果大体一致。总而言之，这些结果强调了不仅是体力活动，还有高质量的睡眠/休息和规律的睡眠/休息模式对于新冠肺炎风险的重要性。我们的发现表明，睡眠替代指标的时间变异性每增加约40分钟，新冠肺炎的风险就会增加约1.2倍，这表明睡眠模式不规律。
Behavioral lifestyle factors are associated with cardiometabolic disease and obesity, which are risk factors for coronavirus disease 2019 (COVID-19). We aimed to investigate whether physical activity, and the timing and balance of physical activity and sleep/rest, were associated with SARS-CoV-2 positivity and COVID-19 severity. Data from 91,248 UK Biobank participants with accelerometer data and complete covariate and linked COVID-19 data to July 19, 2020, were included. The risk of SARS-CoV-2 positivity and COVID-19 severity—in relation to overall physical activity, moderate-to-vigorous physical activity (MVPA), balance between activity and sleep/rest, and variability in timing of sleep/rest—was assessed with adjusted logistic regression. Of 207 individuals with a positive test result, 124 were classified as having a severe infection. Overall physical activity and MVPA were not associated with severe COVID-19, whereas a poor balance between activity and sleep/rest was (odds ratio [OR] per standard deviation: 0.71; 95% confidence interval [CI], 0.62 to 0.81]). This finding was related to higher daytime activity being associated with lower risk (OR, 0.75; 95% CI, 0.61 to 0.93) but higher movement during sleep/rest being associated with higher risk (OR, 1.26; 95% CI, 1.12 to 1.42) of severe infection. Greater variability in timing of sleep/rest was also associated with increased risk (OR, 1.21; 95% CI, 1.08 to 1.35). Results for testing positive were broadly consistent. In conclusion, these results highlight the importance of not just physical activity, but also quality sleep/rest and regular sleep/rest patterns, on risk of COVID-19. Our findings indicate the risk of COVID-19 was consistently approximately 1.2-fold greater per approximately 40-minute increase in variability in timing of proxy measures of sleep, indicative of irregular sleeping patterns.
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