Synthesis of N-linked pentasaccharides with isomeric glycosidic linkage
Synthesis of N-linked pentasaccharides with isomeric glycosidic linkage
复制标题
具有异构糖苷键的N-连接五糖的合成
DOI：
10.1023/a:1007151913476
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发表时间：
2000
影响因子：
3
通讯作者：
Y. Nakahara
中科院分区：
文献类型：
--
作者：
M. Takatani;T. Nakama;Kazusuke Kubo;S. Manabe;Y. Nakahara;Yukishige Ito;Y. Nakahara
作为探索碳水化合物介导的生物相互作用中N-聚糖的结构要求的计划的一部分，N-连接的五糖核心结构在糖苷键方面进行了立体化学修饰。三种异构体，α-D-Man-（1→3）-[α-D-Man-（1→6）]-α-D-Man-（1→ 4）-β-D-GlcNAc-（1→4）-β-D-GlcNAc-L-Asn，α-D-Man-（1→3）-[α-D-Man-（1→6）]-β-D-Man-（1→4）-α-D-GlcNAc-（1→4）-β-D-GlcNAc-L-Asn，和α-D-Man-（1→3）-[α-D-man-（1→6）]-α-D-Man-（1→4）-α-D-GlcNAc-（1→4）-β-D-GlcNAc-L-Asn，合成了还描述了具有天然连接的五糖的合成。
As part of a program to explore the structural requirement of N-glycans in the carbohydrate-mediated biological interactions, N-linked pentasaccharide core structure was stereochemically modified in terms of glycosidic linkage. Three isomers, α-D-Man-(1→3)-[α-D-Man-(1→6)]-α-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc-L-Asn, α-D-Man-(1→3)-[α-D-Man-(1→6)]-β-D-Man-(1→4)-α-D-GlcNAc-(1→4)-β-D-GlcNAc-L-Asn, and α-D-Man-(1→3)-[α-D-man-(1→6)]-α-D-Man-(1→4)-α-D-GlcNAc-(1→4)-β-D-GlcNAc-L-Asn, were synthesized. Synthesis of the pentasaccharide with natural linkage is also described.