Fluorescent trimethyl-substituted naphthyridine as a ligand for C-C mismatch detection in CCG trinucleotide repeats
Fluorescent trimethyl-substituted naphthyridine as a ligand for C-C mismatch detection in CCG trinucleotide repeats
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DOI：
10.1039/c1cc11370d
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Teramae, Norio
中科院分区：
文献类型：
--
作者：
Sato, Yusuke;Honjo, Atsuko;Teramae, Norio
We report on the selective binding of 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND) to C-C mismatch present in the hairpin structures of (CCG)(n) trinucleotide repeats that are associated with neurological diseases; this binding is accompanied by significant fluorescence quenching of ATMND.
