Human genomes as email attachments
Human genomes as email attachments
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DOI：
10.1093/bioinformatics/btn582
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发表时间：
2009-01-15
期刊：
影响因子：
5.8
通讯作者：
Xie, Xiaohui
中科院分区：
文献类型：
--
作者：
Christley, Scott;Lu, Yiming;Xie, Xiaohui
通过公共数据库生成和提供的基因组序列数据量继续以不断扩大的速度增加。对于研究人员来说，下载、复制、共享和操作这些大型数据集变得越来越困难和耗时。我们需要考虑使用先进的压缩技术作为基因组数据标准数据格式的一部分。基因组数据的固有结构允许比通过使用通用压缩程序可以获得的更有效的无损压缩。我们将一系列技术应用于詹姆斯沃森的基因组，将其缩小到仅仅4 MB，小到足以作为电子邮件附件发送。
The amount of genomic sequence data being generated and made available through public databases continues to increase at an ever-expanding rate. Downloading, copying, sharing and manipulating these large datasets are becoming difficult and time consuming for researchers. We need to consider using advanced compression techniques as part of a standard data format for genomic data. The inherent structure of genome data allows for more efficient lossless compression than can be obtained through the use of generic compression programs. We apply a series of techniques to James Watson's genome that in combination reduce it to a mere 4MB, small enough to be sent as an email attachment.