Two photon induced polymerization of organic-inorganic hybrid biomaterials for microstructured medical devices
Two photon induced polymerization of organic-inorganic hybrid biomaterials for microstructured medical devices
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DOI：
10.1016/j.actbio.2006.01.004
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发表时间：
2006-05-01
影响因子：
9.7
通讯作者：
Chichkov, B
中科院分区：
文献类型：
--
作者：
Doraiswamy, A;Jin, C;Chichkov, B
三维微结构医疗器械，包括微针和组织工程支架，是通过 Ormocer(R) 有机-无机杂化材料的两个光子诱导聚合制备的。来自钛：蓝宝石激光器的飞秒激光脉冲用于在小焦点体积内破坏 Irgacure(R) 369 光引发剂上的化学键。自由基化的起始分子与Ormocer US-S4单体反应生成自由基化的多分子。通过使用电流扫描仪和微定位系统在三个维度上移动激光焦点来制造所需的结构。使用两个光子诱导聚合制造的 Ormocer(R) 表面针对 B35 神经母细胞样细胞和 HT 1080 上皮样细胞表现出可接受的细胞活力和细胞生长特征。使用两个光子诱导聚合创建了类似乐高®的联锁组织工程支架和具有独特几何形状的微针阵列。这些结果表明，与化学各向同性蚀刻、注射成型、反应离子蚀刻、表面微机械加工、体微机械加工、多晶硅微成型、光刻-电铸-复制或其他传统微加工技术相比，两个光子诱导聚合能够制造尺寸、形状和材料范围更大的医疗微型器件。 (C) 2006 Acta Materialia Inc. 由 Elsevier Ltd 出版。保留所有权利。
Three-dimensional microstructured medical devices, including microneedles and tissue engineering scaffolds, were fabricated by two photon induced polymerization of Ormocer(R) organic-inorganic hybrid materials. Femtosecond laser pulses from a titanium: sapphire laser were used to break chemical bonds on Irgacure(R) 369 photoinitiator within a small focal volume. The radicalized starter molecules reacted with Ormocer(R) US-S4 monomers to create radicalized polymolecules. The desired structures are fabricated by moving the laser focus in three dimensions using a galvano-scanner and a micropositioning system. Ormocer(R) surfaces fabricated using two photon induced polymerization demonstrated acceptable cell viability and cell growth profiles against B35 neuroblast-like cells and HT 1080 epithelial-like cells. Lego(R)-like interlocking tissue engineering scaffolds and microneedle arrays with unique geometries were created using two photon induced polymerization. These results suggest that two photon induced polymerization is able to create medical microdevices with a larger range of sizes, shapes, and materials than chemical isotropic etching, injection molding.. reactive ion etching, surface micromachining, bulk micromachining, polysilicon micrornolding, lithography-electroforming-replication, or other conventional microfabrication techniques. (C) 2006 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.