Prostate size and risk of high-grade, advanced prostate cancer and biochemical progression after radical prostatectomy: A search database study
Prostate size and risk of high-grade, advanced prostate cancer and biochemical progression after radical prostatectomy: A search database study
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DOI：
10.1200/jco.2005.05.525
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发表时间：
2005-10-20
影响因子：
45.3
通讯作者：
Kane, CJ
中科院分区：
文献类型：
--
作者：
Freedland, SJ;Isaacs, WB;Kane, CJ
目的前列腺的生长和分化受雄激素控制，先前的研究表明，性腺功能减退的男性发生的肿瘤更具侵袭性。我们检查前列腺重量是否与肿瘤分级、晚期疾病或根治性前列腺切除术（RP）后生化进展风险相关。患者和方法我们使用逻辑回归评估前列腺重量与病理肿瘤分级、阳性手术切缘、囊外疾病和精囊浸润的相关性，并使用考克斯比例风险回归评估前列腺重量与生化进展的相关性，在1988年至2003年期间，在五个平等医疗中心接受BP治疗的602名男性，这些中心组成了共享平等医疗区域癌症医院（Shared Equal Access Regional Cancer Hospital，简称ESCC）数据库。手术切缘阳性，囊外扩张（所有P = 100 g：相对危险度= 8.43; 95% CI，2.9 - 24.0; P <0.001）。在术前经直肠超声测量的前列腺体积与高级别疾病、手术切缘阳性、囊外扩张之间也存在类似的相关性（均P
Purpose Prostate growth and differentiation are under androgenic control, and prior studies suggested that tumors that develop in hypogonadal men are more aggressive. We examined whether prostate weight was associated with tumor grade, advanced disease, or risk of biochemical progression after radical prostatectomy (RP).Patients and Methods We evaluated the association of prostate weight with pathologic tumor grade, positive surgical margins, extracapsular disease, and seminal vesicle invasion using logistic regression and with biochemical progression using Cox proportional hazards regression among 1,602 men treated with BP between 1988 and 2003 at five equal-access medical centers, which composed the Shared Equal Access Regional Cancer Hospital (SEARCH) Database.Results In outcome prediction models including multiple predictor variables, it was found that the predictor variable of prostate weight was significantly inversely associated with the outcomes of high-grade disease, positive surgical margins, extracapsular extension (all P = 100 g: relative risk = 8.43; 95% CI, 2.9 to 24.0; P < .001). Similar associations were seen between preoperative transrectal ultrasound-measured prostate volume and high-grade disease, positive surgical margins, extracapsular extension (all P