Cerebrospinal fluid total tau as a marker of Alzheimer's disease intensity
Cerebrospinal fluid total tau as a marker of Alzheimer's disease intensity
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DOI：
10.1002/gps.2353
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发表时间：
2010-04-01
影响因子：
4
通讯作者：
Londos, Elisabet
中科院分区：
文献类型：
--
作者：
Samgard, Kaisa;Zetterberg, Henrik;Londos, Elisabet
目的：这项纵向研究的目的是验证一种假设，即阿尔茨海默病患者的脑脊液生物标志物也可能是一种前瞻性指标，不仅与认知障碍的程度和特征有关，而且与认知能力随时间的变化有关。方法：在这里，我们评估了142例阿尔茨海默病患者脑脊液A β 42、T-tau和P-tau与疾病严重程度的神经心理学评分以及疾病进展率的关系。所有患者都参加了一项为期3年的前瞻性纵向治疗研究。结果：与T-tau水平较低的阿尔茨海默病患者相比，T-tau水平高于上四分位数（800 ng/L）的AD患者MM SE评分降低的进展更快（p = 0.008）。我们还发现，与T-tau患者相比，T-tau > 800 ng/L的个体在MMSE和DAS cog评估时的总分表现更差，尤其是在记忆和定向方面
Objectives: The aim of this longitudinal study was to test the hypothesis that CSF biomarkers in AD patients also may be forward-looking measures that are associated not only with the degree and profile of cognitive impairment but also with changes in cognition over time.Methods: Here, we assessed the association of CSF A beta 42, T-tau and P-tau with neuropsychological scores of disease severity, as well as the rate of disease progression, in 142 patients with Alzheimer's disease. All patients were part of a 3-year prospective longitudinal treatment study.Results: A more rapid progress in MM SE score reduction was seen in AD patients with T-tau levels higher than the upper quartile (800 ng/L) compared with Alzheimer's disease patients with lower T-tau levels (p = 0.008). We also found that individuals with T-tau > 800 ng/L performed worse in total scores and especially in memory and orientation when assessed with MMSE and A DAS cog than patients with T-tau