Cardiomyocyte-Driven Structural Color Actuation in Anisotropic Inverse Opals
Cardiomyocyte-Driven Structural Color Actuation in Anisotropic Inverse Opals
复制标题
各向异性反蛋白石中心肌细胞驱动的结构颜色驱动。
DOI：
10.1021/acsnano.8b08230
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发表时间：
2019-01-01
期刊：
影响因子：
17.1
通讯作者：
Zhao, Yuanjin
中科院分区：
文献类型：
--
作者：
Shang, Yixuan;Chen, Zhuoyue;Zhao, Yuanjin
由生物组织和人工材料组成的生物混合致动器因其能动态感知复杂的生物电信号并与之相互作用而受到广泛关注。在此，基于具有周期性椭圆大孔的各向异性反蛋白石基底和水凝胶填充物，设计了一种具有自驱动和自报告反馈的复合生物混合驱动器。水凝胶的各向异性表面形貌和高生物相容性的益处是，植入的心肌细胞可以被诱导成高度有序的排列，并在弹性基底上恢复自主搏动能力。由于心肌细胞搏动过程中细胞的伸长和收缩，各向异性的反蛋白石衬底经历了一个同步的变形驱动周期，这可以报告为它们的光子带隙和结构色的相应位移。这些自驱动的生物混合致动器可以用作软体结构色机器人的构造元件，例如具有摆动尾巴的仿生孔雀鱼。此外，随着自驱动生物混合驱动器和微流体技术的集成，先进的芯片上的心脏系统已开发出具有微生理可视化功能的集成细胞监测和药物测试。这种各向异性反蛋白石生物混合驱动器在生物医学工程中有着广泛的应用前景。
Biohybrid actuators composed of living tissues and artificial materials have attracted increasing interest in recent years because of their extraordinary function of dynamically sensing and interacting with complex bioelectrical signals. Here, a compound biohybrid actuator with self-driven actuation and self-reported feedback is designed based on an anisotropic inverse opal substrate with periodical elliptical macropores and a hydrogel filling. The benefit of the anisotropic surface topography and high biocompatibility of the hydrogel is that the planted cardiomyocytes could be induced into a highly ordered alignment with recovering autonomic beating ability on the elastic substrate. Because of the cell elongation and contraction during cardiomyocyte beating, the anisotropic inverse opal substrates undergo a synchronous cycle of deformation actuations, which can be reported as corresponding shifts of their photonic band gaps and structural colors. These self-driven biohybrid actuators could be used as elements for the construction of a soft-bodied structural color robot, such as a biomimetic guppy with a swinging tail. Besides, with the integration of a self-driven biohybrid actuator and microfluidics, the advanced heart-on-a-chip system with the feature of microphysiological visuality has been developed for integrated cell monitoring and drug testing. This anisotropic inverse opal-derived biohybrid actuator could be widely applied in biomedical engineering.