Membrane dynamics in mammalian embryogenesis: Implication in signal regulation.
Membrane dynamics in mammalian embryogenesis: Implication in signal regulation.
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DOI：
10.1002/bdrc.21124
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发表时间：
2016-03
期刊：
影响因子：
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通讯作者：
Y. Wada;G. Sun-Wada;N. Kawamura;Jyunichiro Yasukawa
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文献类型：
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作者：
Y. Wada;G. Sun-Wada;N. Kawamura;Jyunichiro Yasukawa
真核生物已经进化出一系列的膜隔室，这些隔室构成了允许物质流动的分泌和内吞途径。这两种途径都发挥着重要的调节作用。分泌途径对于细胞外分泌信号分子的产生是必不可少的，但其功能不仅限于连接细胞内和细胞外区室的途径。翻译后修饰也在分泌途径中发挥不可或缺的功能，并参与发育调节。内吞途径作为一个平台，将信号从细胞外刺激传递到细胞内介质，然后最终诱导信号终止。在这里，我们讨论了最近的研究表明，在膜动力学功能障碍导致图案缺陷的胚胎发育和组织形态发生在哺乳动物。
Eukaryotes have evolved an array of membrane compartments constituting secretory and endocytic pathways that allow the flow of materials. Both pathways perform important regulatory roles. The secretory pathway is essential for the production of extracellular, secreted signal molecules, but its function is not restricted to a mere route connecting intra- and extracellular compartments. Post-translational modifications also play an integral function in the secretory pathway and are implicated in developmental regulation. The endocytic pathway serves as a platform for relaying signals from the extracellular stimuli to intracellular mediators, and then ultimately inducing signal termination. Here, we discuss recent studies showing that dysfunction in membrane dynamics causes patterning defects in embryogenesis and tissue morphogenesis in mammals.