Fe(salan)-catalyzed asymmetric oxidation of sulfides with hydrogen peroxide in water
Fe(salan)-catalyzed asymmetric oxidation of sulfides with hydrogen peroxide in water
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DOI：
10.1021/ja071916
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发表时间：
2007-07-25
影响因子：
15
通讯作者：
Katsuki, Tsutomu
中科院分区：
文献类型：
--
作者：
Egami, Hiromichi;Katsuki, Tsutomu
合成了一种新的手性Fe（salan）配合物，并在无表面活性剂的水溶液中对H2O2不对称氧化硫化物反应进行了催化研究。不仅烷基芳基硫醚，而且各种甲基烷基硫醚都被氧化为相应的亚砜，对映选择性高达96%ee。值得注意的是，配合物4的转换数达8000。
A new chiral Fe(salan) complex was synthesized, and it was found to serve as an efficient catalyst for asymmetric oxidation of sulfides using hydrogen peroxide in water without surfactant. Not only alkyl aryl sulfides but also various methyl alkyl sulfides were oxidized to the corresponding sulfoxides with high enantioselectivities up to 96% ee. It should be noted that the turnover number of complex 4 amounts to 8000.