A preliminary study of D-cycloserine augmentation of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder.
A preliminary study of D-cycloserine augmentation of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder.
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DOI：
10.1016/j.biopsych.2010.07.015
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发表时间：
2010-12-01
影响因子：
10.6
通讯作者：
Geller, Daniel A.
中科院分区：
文献类型：
--
作者：
Storch, Eric A.;Murphy, Tanya K.;Goodman, Wayne K.;Geffken, Gary R.;Lewin, Adam B.;Henin, Aude;Micco, Jamie A.;Sprich, Susan;Wilhelm, Sabine;Bengtson, Michael;Geller, Daniel A.
Research on the neural circuitry underlying fear extinction has led to the examination of d-cycloserine (DCS), a partial agonist at the NMDA receptor in the amygdala, as a method of enhancing exposure therapy outcome. Preliminary results have supported the use of DCS to augment exposure therapy in adult anxiety disorders; however, no data have been reported in any childhood anxiety disorder. Thus, we sought to preliminarily examine if weight-adjusted DCS doses (25 or 50mg) enhanced the overall efficacy of cognitive-behavioral therapy (CBT) for pediatric obsessive-compulsive disorder (OCD). Participants were 30 youth (ages 8–17) with a primary diagnosis of OCD. The study design was a randomized, double-blinded, placebo-controlled augmentation trial examining CBT+DCS versus CBT+Placebo (15 youth per group). All patients received 7 E/RP sessions paired with DCS or placebo taken 1 hour prior to sessions. Although not significantly different, compared to the CBT+Placebo group, youth in the CBT+DCS arm showed small-to-moderate treatment effects (d=.31 to .47 on primary outcomes). No adverse events were recorded. The present results complement findings in adult OCD and non-OCD anxiety disorders and provide initial support for a more extensive study of DCS augmentation of CBT among youth with OCD.
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作者：
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通讯作者：
Otto, MW
影响因子：
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通讯作者：
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影响因子：
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影响因子：
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