THE ROLE OF O-2-CENTER-DOT- IN THE PRODUCTION OF HO-CENTER-DOT - IN-VITRO AND IN-VIVO
THE ROLE OF O-2-CENTER-DOT- IN THE PRODUCTION OF HO-CENTER-DOT - IN-VITRO AND IN-VIVO
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DOI：
10.1016/0891-5849(94)90239-9
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发表时间：
1994-01-01
影响因子：
7.4
通讯作者：
FRIDOVICH, I
中科院分区：
文献类型：
--
作者：
LIOCHEV, SI;FRIDOVICH, I
体外O2。-将Fe（III）还原为Fe（II），Fe（II）又还原H2O2，产生Fe（II）O或HO。体内O2-增加游离铁的供应，通过氧化攻击的[4Fe-4S]簇的脱氢酶，使他们释放Fe（II），然后可以减少H2O2。in vivo.氧气还通过作为氧化剂作用于脱氢酶和其它细胞还原剂而增加H2O2的产生。
In vitro O2.- reduces Fe(III) to Fe(II), which, in turn, reduces the H2O2, yielding Fe(II)O or HO.. In vivo O2.-increases the supply of free iron by oxidatively attacking the [4Fe-4S] clusters of dehydratases such that they release Fe(II), which can then reduce H2O2. In vivo. O2.- also increases the production of H2O2 by acting as an oxidant toward the dehydratases and toward other cellular reductants.