Hemagglutinin sequence clusters and the antigenic evolution of influenza A virus
Hemagglutinin sequence clusters and the antigenic evolution of influenza A virus
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DOI：
10.1073/pnas.082110799
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发表时间：
2002-04-30
影响因子：
11.1
通讯作者：
Levin, SA
中科院分区：
文献类型：
--
作者：
Plotkin, JB;Dushoff, J;Levin, SA
甲型流感病毒血凝素（HA）基因的连续突变产生了新的抗原株，导致每年的流行病。使用560个病毒RNA序列的数据库，我们研究了过去二十年HA进化的结构和克里思。我们检测到一个临界长度尺度，在氨基酸空间中，HA序列聚集成簇，或成群。我们调查了病毒群的时空分布，并将其与世界卫生组织推荐的流感疫苗的时间序列进行了比较。我们介绍了一种预测未来显性HA氨基酸序列的方法，并讨论了其潜在的相关性，疫苗的选择。我们还研究了簇结构和HA蛋白的主要抗体结合区域之间的关系。
Continual mutations to the hemagglutinin (HA) gene of influenza A virus generate novel antigenic strains that cause annual epidemics. Using a database of 560 viral RNA sequences, we study the structure and tempo of HA evolution over the past two decades. We detect a critical length scale, in amino acid space, at which HA sequences aggregate into clusters, or swarms. We investigate the spatio-temporal distribution of viral swarms and compare it to the time series of the influenza vaccines recommended by the World Health Organization. We introduce a method for predicting future dominant HA amino acid sequences and discuss its potential relevance to vaccine choice. We also investigate the relationship between cluster structure and the primary antibody-combining regions of the HA protein.