RELATIONSHIP BETWEEN DEGREE OF OBESITY AND INVIVO INSULIN ACTION IN MAN
RELATIONSHIP BETWEEN DEGREE OF OBESITY AND INVIVO INSULIN ACTION IN MAN
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DOI：
10.1152/ajpendo.1985.248.3.e286
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发表时间：
1985-01-01
影响因子：
--
通讯作者：
REAVEN, G
中科院分区：
文献类型：
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作者：
BOGARDUS, C;LILLIOJA, S;REAVEN, G
与瘦对照组相比，肥胖受试者体内胰岛素作用降低。关于肥胖程度和胰岛素作用之间的关系，目前几乎没有数据，而且这种关系并不独立于最大有氧能力的个体差异。五十五名男性皮马印第安人和35名男性高加索人正常葡萄糖耐量进行了研究。在血浆胰岛素浓度为apprx时，使用高胰岛素血正葡萄糖钳夹技术测量体内胰岛素作用。100 μ U/ml。通过密度测定法测定身体成分，并使用分级运动试验估计最大有氧能力。肥胖程度与体内胰岛素作用呈非线性相关。在印度人和高加索人中，随着肥胖的增加，胰岛素的作用显著下降，高达. apprx的体脂百分比。28- 30%印度人肥胖的进一步增加与胰岛素作用的显著变化无关。在两个种族组中，最大有氧能力与胰岛素作用在整个胰岛素作用范围内呈线性正相关。肥胖程度和最大有氧能力分别与胰岛素作用独立相关，尽管这些独立关系在高加索人中的意义不大。肥胖和最大有氧能力的个体差异仅占这些葡萄糖耐量受试者中观察到的胰岛素作用变异性的一半。
In vivo insulin action is reduced in obese subjects compared with lean controls. Little data is available on the relationship between degree of obesity and insulin action and this relationship is not independent of individual differences in maximal aerobic capacity. Fifty-five male Pima Indians and 35 male Caucasians with normal glucose tolerance were studied. In vivo insulin action was measured using the hyperinsulinemic, euglycemic clamp technique at a plasma insulin concentration of .apprx. 100 .mu.U/ml. Body composition was determined by densitometry and maximal aerobic capacity was estimated using a graded exercise test. Degree of obesity was nonlinearly related to in vivo insulin action. In both Indians and Caucasians there was a significant decline in insulin action with increasing obesity up to a percent body fat of .apprx. 28-30%. Further increases in obesity in the Indians were not associated with significant changes in insulin action. Maximal aerobic capacity was positively linearly correlated with insulin action over the entire range of insulin action in both racial groups. Degree of obesity and maximal aerobic capacity were each independently associated with insulin action although these independent relationships were of marginal significance in the Causacians. Individual differences in obesity and maximal aerobic capacity accounted for only half the variability observed in insulin action in these glucose tolerant subjects.